BuChE-IN-6
BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ42 self-aggregation.
For research use only. We do not sell to patients.
- CAS No.: 2003213-07-6
- Formula: C21H26N4O2
- Molecular Weight:366.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
53.8 μM
Compound: 1b
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36092141] |
| HEK293 | IC50 |
23.1 μM
Compound: 1b
|
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36092141] |
| MCF-10A | IC50 |
1.08 μM
Compound: 1b
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Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36092141] |
| MCF7 | IC50 |
1.34 μM
Compound: 1b
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36092141] |
| MDA-MB-231 | IC50 |
1.79 μM
Compound: 1b
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 36092141] |
| SW480 | IC50 |
8.9 μM
Compound: 1b
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Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 36092141] |
Chemical Information
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CAS No. 2003213-07-6
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Molecular Weight 366.46
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Formula C21H26N4O2
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SMILES
O=C1N(CC2=CN([C@@H]3[C@H](C(C)C)CC[C@@H](C)C3)N=N2)C4=C(C=CC=C4)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BuChE-IN-6 Related Classifications
HY-146251 Related Classifications
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