Acyltransferase Inhibitor

Acyltransferase Inhibitors (207):

Cat. No.	상품명	효과	Purity

HY-138942

PF-06427878	Inhibitor
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 (DGAT2) inhibitor with IC₅₀s of 99 nM and 202 nM for human and rat DGAT2, respectively. PF-06427878 shows greater than 470-fold selectivity for DGAT2 over DGAT1, MGAT1, MGAT2 and MGAT3. PF-06427878 can improve liver steatosis and function. PF-06427878 can be used for the study of nonalcoholic fatty liver diseases.

HY-19140

YM-17E hydrochloride	Inhibitor
YM17E hydrochloride is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor, with IC₅₀ of 44 nM. YM17E hydrochloride has hypocholesterolemic effect.

HY-N10234

Phenylpyropene A	Inhibitor
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM.

HY-16149

SDZ-CPI 975	Inhibitor
SDZ-CPI-975 is a novel, reversible, and selective CPT I inhibitor. SDZ-CPI-975 effectively inhibits fatty acid oxidation and lowers blood glucose levels.

HY-182273

DM243	Inhibitor
DM243 is an EPAC1 activator and STAT3 modulator with an pIC₅₀ of 4.769 for EPAC1. DM243 increases GTP-bound Rap1 levels in EPAC1-expressing cells. DM243 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM243 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing α-smooth muscle actin and Collagen I levels in lung fibroblasts. DM243 exhibits minimal cytotoxicity in normal human lung fibroblasts.

HY-106938

Eldacimibe	Inhibitor
Eldacimibe is an ACAT2 inhibitor. Eldacimibe can lower plasma cholesterol levels by blocking cholesterol absorption and can prevent macrophages from turning into foam cells. Eldacimibe can be used in the study of cardiovascular diseases (atherosclerosis), endocrine and metabolic diseases (hypercholesterolemia) .

HY-129344

CL 277082	Inhibitor
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor.

HY-U00430

MGAT2-IN-2	Inhibitor
MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC₅₀ of 3.4 nM.

HY-153507

DGAT1-IN-4	Inhibitor
DGAT1-IN-4 is a potent, orally active, and selective DGAT1 inhibitor with an IC₅₀ of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT1-IN-4 can be used for the research of obesity.

HY-N8331

Terpendole I	Inhibitor
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism.

HY-145624B

Obeversen sodium scrambled negative control	Inhibitor
Obeversen sodium scrambled negative control is the sequence scrambled negative control of Obeversen sodium.

HY-16278A

Pradigastat sodium	Inhibitor
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro.

HY-145624

Obeversen	Inhibitor
Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease.

HY-133488

ST1072	Inhibitor
ST1072 is a dual inhibitor of CerS4 and CerS6. ST1072 significantly reduces the ability of murine T cells to proliferate and produce IFN-γ. ST1072 can be used for hematologic malignancies research.

HY-139027

ACAT-IN-10	Inhibitor
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription.

HY-179397

AANAT-IN-2	Inhibitor
AANAT-IN-2 (Compound 5g) is a potent and selective AANAT inhibitor, with an IC₅₀ of 1.1 μM. AANAT-IN-2 can be used for the study of seasonal affective disorder (SAD).

HY-149893

MGAT2-IN-4	Inhibitor
MGAT2-IN-4 (compound 33) is an inhibitor of monoacylglycerol transferase 2 (MGAT2), with liver metabolic stability. MGAT2-IN-4 can be used for research on obesity, diabetes and non-alcoholic steatohepatitis (NASH).

HY-122078

FR-190809	Inhibitor
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC₅₀ of 45 nM.

HY-162854

Diacylglycerol acyltransferase inhibitor-2	Inhibitor
Diacylglycerol acyltransferase inhibitor-2 (Example 8) is an inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC₅₀ value of 3.7 nM.

HY-145624A

Obeversen sodium	Inhibitor
Obeversen sodium is an antisense oligonucleotide that inhibits the synthesis of Diacylglycerol acyltransferase 2 (DGAT-2). Obeversen sodium can be used in the research of nonalcoholic fatty liver disease.

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