1. Metabolic Enzyme/Protease
  2. Acyltransferase

FR-190809 

Cat. No.: HY-122078
Handling Instructions

FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM.

For research use only. We do not sell to patients.

FR-190809 Chemical Structure

FR-190809 Chemical Structure

CAS No. : 215589-63-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].

IC50 & Target

IC50: (ACAT)[1]

In Vitro

FR-190809 inhibits foam cell formation with an IC50 of 215 nM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6564 mL 8.2818 mL 16.5637 mL
5 mM 0.3313 mL 1.6564 mL 3.3127 mL
10 mM 0.1656 mL 0.8282 mL 1.6564 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

603.73

Formula

C₂₉H₃₄FN₃O₆S₂

CAS No.

215589-63-2

SMILES

O=C(NC1=C(S(=O)(C)=O)C=C(C)N=C1S(=O)(C)=O)N(C2CCCCCC2)CC3=CC=C(OC4=CC=C(F)C=C4)C=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
FR-190809
Cat. No.:
HY-122078
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FR-190809

Cat. No.: HY-122078