CL 277082
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 96224-26-9
- Formula: C26H36F2N2O
- Molecular Weight:430.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CL 277082 inhibits ACAT in cultured smooth muscle cells (IC50 = 0.8 μM). CL 277082 does not inhibit fatty acid incorporation into triglycerides or phospholipids. CL 277082 does not inhibit other cholesterol esterifying enzymes such as lecithin:cholesterol acyltransferase (LCAT) and pancreatic cholesterol esterase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96224-26-9
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Molecular Weight 430.57
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Formula C26H36F2N2O
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SMILES
O=C(NC1=CC=C(F)C=C1F)N(CC2=CC=C(CC(C)(C)C)C=C2)CCCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CL 277082 Related Classifications
HY-129344 Related Classifications
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