96224-26-9
Chemical Structure
CL 277082
- CAS No.: 96224-26-9
- Formula:C26H36F2N2O
- Molecular Weight:430.57
IUPAC Name: 3-(2,4-difluorophenyl)-1-heptyl-1-(4-neopentylbenzyl)urea
InChIKey: QKJLDOBXDUVGEE-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(F)C=C1F)N(CC2=CC=C(CC(C)(C)C)C=C2)CCCCCCC
Biological Activity: CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor[1].
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CL 277082 | CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor. | |||||||||||||||||||||
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Keywords
