2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W015580
    (+)-Fenchone
    		Inhibitor 99.88%
    (+)-Fenchone is an antibacterial agent. (+)-Fenchone interferes with bacterial fatty acid synthesis, disrupts fungal cell wall construction, and inhibits bacterial biofilm formation. (+)-Fenchone can be used in studies related to bacterial and fungal infections.
    (+)-Fenchone
  • HY-B0421R
    Mycophenolic acid (Standard)
    		Inhibitor
    Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
    Mycophenolic acid (Standard)
  • HY-W392026
    Polyhexamethyleneguanidine hydrochloride
    		Inhibitor
    Polyhexamethyleneguanidine (PHMGH) hydrochloride is a positively charged polymer with broad-spectrum antimicrobial activity. It exerts its antibacterial effects by binding to the cell membranes of bacteria and fungi, disrupting membrane integrity. Polyhexamethyleneguanidine hydrochloride can be applied in studies related to disinfection, water treatment, pesticides, and other fields[2]
    Polyhexamethyleneguanidine hydrochloride
  • HY-B0101R
    Fluconazole (Standard)
    		Inhibitor
    Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL.
    Fluconazole (Standard)
  • HY-W009335
    Iodopropynyl butylcarbamate
    		Inhibitor 99.54%
    Iodopropynyl butylcarbamate (IPBC) is a potent fungicide and preservative, which has been used in the paints, coatings, wood preservatives, personal care, and cosmetics industries.
    Iodopropynyl butylcarbamate
  • HY-126810A
    NP213 TFA
    		Inhibitor 98.04%
    NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections.
    NP213 TFA
  • HY-P3512
    Iseganan
    		Inhibitor 98.87%
    Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research.
    Iseganan
  • HY-P10304A
    Cyclo(Arg-Pro) TFA
    		Inhibitor 98.59%
    Cyclo (Arg-Pro) TFA is a chitinase inhibitor. Cyclo (Arg-Pro) TFA disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. Cyclo (Arg-Pro) TFA prevents cell separation of Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Cyclo (Arg-Pro) TFA blocks the morphological transition of Candida albicans from yeast form to hyphal form, without inhibiting cell growth.
    Cyclo(Arg-Pro) TFA
  • HY-B1144A
    Chlormidazole hydrochloride
    		Inhibitor 99.45%
    Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses.
    Chlormidazole hydrochloride
  • HY-W089845
    Heneicosane
    		Inhibitor 99.72%
    Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs.
    Heneicosane
  • HY-N7364R
    (E)-β-Farnesene (Standard)
    		Inhibitor
    (E)-β-Farnesene (Standard) is the analytical standard of (E)-β-Farnesene. This product is intended for research and analytical applications. (E)-β-Farnesene (trans-β-Farnesene) is a volatile sesquiterpene hydrocarbon which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.
    (E)-β-Farnesene (Standard)
  • HY-B2144I
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
    		Inhibitor
    Chitosan (Deacetylated chitin) (≥90% deacetylated,viscosity 10 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated,viscosity 10 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
  • HY-W004643
    Akardite II
    		Inhibitor 99.99%
    Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants as it scavenges NOx. Akardite II helps control a variety of plant pathogens and weeds, which can be used as fungicides and herbicides.
    Akardite II
  • HY-135258
    Galactinol dihydrate
    		Inhibitor 98.0%
    Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot.
    Galactinol dihydrate
  • HY-B1978
    Iprodione
    		Inhibitor 99.25%
    Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.
    Iprodione
  • HY-W004263
    1-Eicosanol
    		Inhibitor 99.02%
    1-Eicosanol (Arachidyl alcohol) is a long-chain fatty alcohol and volatile organic compound that can be isolated from the leaves of Leea indica and produced by Bacillus velezensis ZJ1. 1-Eicosanol inhibits mycelial growth of Alternaria solani and Botrytis cinerea. 1-Eicosanol is applicable to research related to tomato early blight and tomato gray mold.
    1-Eicosanol
  • HY-108485
    Damnacanthal
    		Inhibitor 99.40%
    Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans.
    Damnacanthal
  • HY-128467
    Dehydroacetic acid sodium
    		Inhibitor 99.87%
    Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
    Dehydroacetic acid sodium
  • HY-B2140
    Multifungin
    		Inhibitor 99.19%
    Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral candidiasis. Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn.
    Multifungin
  • HY-111009
    Swinholide A
    		Inhibitor 98.30%
    Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity.
    Swinholide A
Cat. No. Product Name / Synonyms Application Reactivity