1. Anti-infection
  2. Fungal
  3. NP213 TFA

NP213 TFA 

Cat. No.: HY-126810A Purity: 95.23%
Handling Instructions

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NP213 TFA Chemical Structure

NP213 TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 571 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
10 mg USD 430 In-stock
Estimated Time of Arrival: December 31
25 mg USD 760 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections[1][2].

IC50 & Target

IC50: fungal[1]

In Vitro

NP213 (500-1000 μg/mL; 18 hours) increases the number of PI-stained T. rubrum NCPF0118 cells in samples. This results suggests that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization[1].
NP213 is against T. rubrum NCPF0118, shows different MIC values against T. rubrum NCPF0118, and the MICs varies depending on the source of the keratin. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin and Lamb’s wool Keratin, respectively[1].NP213 TFA (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus spp and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 µg/ml[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[3]

Cell Line: Clinically relevant yeast isolates
Concentration: 0 μg/ml; 0.125 μg/ml; 0.25 μg/ml; 0.5 μg/ml; 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml
Incubation Time: 2 h, 2.5 h, 4 h
Result: Decreased isolates growth as a dose-dependent manner.
In Vivo

NP213 TFA (25 mg/kg) is well tolerated in mice. In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1207.32

Formula

C₄₄H₈₅F₃N₂₈O₉

Sequence

Cyclo-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

Cyclo-RRRRRRR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: 95.23%

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Keywords:

NP213NP 213NP-213FungalNailfungusAMPantimicrobialpeptideinfectiononychomycosisanti-fungalInhibitorinhibitorinhibit

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NP213 TFA
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HY-126810A
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