1. Anti-infection
  2. Fungal
  3. NP213 TFA

NP213 TFA 

Cat. No.: HY-126810A
Handling Instructions

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NP213 TFA Chemical Structure

NP213 TFA Chemical Structure

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Description

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections[1][2].

IC50 & Target

IC50: fungal[1]

In Vitro

NP213 (500-1000 μg/mL; 18 hours) increases the number of PI-stained T. rubrum NCPF0118 cells in samples. This results suggests that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization[1].
NP213 is against T. rubrum NCPF0118, shows different MIC values against T. rubrum NCPF0118, and the MICs varies depending on the source of the keratin. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin and Lamb’s wool Keratin, respectively[1].NP213 TFA (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus spp and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 µg/ml[3].

Cell Cytotoxicity Assay[3]

Cell Line: Clinically relevant yeast isolates
Concentration: 0 μg/ml; 0.125 μg/ml; 0.25 μg/ml; 0.5 μg/ml; 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml
Incubation Time: 2 h, 2.5 h, 4 h
Result: Decreased isolates growth as a dose-dependent manner.
In Vivo

NP213 TFA (25 mg/kg) is well tolerated in mice. In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h[3].

Molecular Weight

1207.32

Formula

C₄₄H₈₅F₃N₂₈O₉

Sequence

Cyclo-{Arg}{Arg}{Arg}{Arg}{Arg}{Arg}{Arg}

Sequence Shortening

Cyclo-RRRRRRR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NP213NP 213NP-213FungalNailfungusAMPantimicrobialpeptideinfectiononychomycosisanti-fungalInhibitorinhibitorinhibit

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NP213 TFA
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HY-126810A
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