Iseganan
Based on 1 Customer Validation
Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research.
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 257277-05-7
- Formula: C78H126N30O18S4
- Molecular Weight:1900.28
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Iseganan (200 and 400 μg/mL; 24 h) disrupts T. crassiceps cysticerci in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cysticerci
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Concentration:200 and 400 μg/mL
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Incubation Time:24 hours
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Result:Showed loss of motility, size decreasement, as well as disruption of the bladder wall.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/cAnN mice injected with T. crassiceps[3]
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Dosage:200 and 400 μg per mouse
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Administration:Intraperitoneal injection; 200 and 400 μg per mouse; once
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Result:Reduced the parasite load by 25% when compared with the control group.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 257277-05-7
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Appearance Solid
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Molecular Weight 1900.28
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Formula C78H126N30O18S4
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Color White to off-white
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Synonyms
IB-367
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Sequence Shortening
RGGLCYCRGRFCVCVGR-NH2 (Disulfide bridge:Cys5-Cys14, Cys7-Cys12)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 100 mg/mL (52.62 mM; Need ultrasonic)
DMSO : 25 mg/mL (13.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Toney JH. Iseganan (IntraBiotics pharmaceuticals). Curr Opin Investig Drugs. 2002 Feb;3(2):225-8. [Content Brief]
[2]. Giles FJ, et al. Iseganan HCl: a novel antimicrobial agent. Expert Opin Investig Drugs. 2002 Aug;11(8):1161-70. [Content Brief]
[3]. Landa A, et al. Antimicrobial peptides (Temporin A and Iseganan IB-367): effect on the cysticerci of Taenia crassiceps. Mol Biochem Parasitol. 2009 Apr;164(2):126-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 0.5262 mL | 2.6312 mL | 5.2624 mL | 13.1560 mL |
| 5 mM | 0.1052 mL | 0.5262 mL | 1.0525 mL | 2.6312 mL | |
| 10 mM | 0.0526 mL | 0.2631 mL | 0.5262 mL | 1.3156 mL | |
| H2O | 15 mM | 0.0351 mL | 0.1754 mL | 0.3508 mL | 0.8771 mL |
| 20 mM | 0.0263 mL | 0.1316 mL | 0.2631 mL | 0.6578 mL | |
| 25 mM | 0.0210 mL | 0.1052 mL | 0.2105 mL | 0.5262 mL | |
| 30 mM | 0.0175 mL | 0.0877 mL | 0.1754 mL | 0.4385 mL | |
| 40 mM | 0.0132 mL | 0.0658 mL | 0.1316 mL | 0.3289 mL | |
| 50 mM | 0.0105 mL | 0.0526 mL | 0.1052 mL | 0.2631 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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