2. Anti-infection
  3. Bacterial Fungal Parasite
  4. Iseganan

Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Iseganan Chemical Structure

Iseganan Chemical Structure

CAS No. : 257277-05-7

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1 mg USD 210 In-stock
5 mg USD 510 In-stock
10 mg USD 820 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research[1][2][3].

In Vitro

Iseganan (200 and 400 μg/mL; 24 h) disrupts T. crassiceps cysticerci in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iseganan Related Antibodies

Cell Viability Assay[3]

Cell Line: Cysticerci
Concentration: 200 and 400 μg/mL
Incubation Time: 24 hours
Result: Showed loss of motility, size decreasement, as well as disruption of the bladder wall.
In Vivo

Iseganan (intraperitoneal injection; 200 and 400 μg per mouse; once) shows anti-parasite activity in T. crassiceps murine cysticercosis model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/cAnN mice injected with T. crassiceps[3]
Dosage: 200 and 400 μg per mouse
Administration: Intraperitoneal injection; 200 and 400 μg per mouse; once
Result: Reduced the parasite load by 25% when compared with the control group.
Clinical Trial
Molecular Weight

1900.28

Formula

C78H126N30O18S4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RGGLCYCRGRFCVCVGR-NH2 (Disulfide bridge:Cys5-Cys14, Cys7-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (52.62 mM; Need ultrasonic)

DMSO : 25 mg/mL (13.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5262 mL 2.6312 mL 5.2624 mL
5 mM 0.1052 mL 0.5262 mL 1.0525 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.5262 mL 2.6312 mL 5.2624 mL 13.1560 mL
5 mM 0.1052 mL 0.5262 mL 1.0525 mL 2.6312 mL
10 mM 0.0526 mL 0.2631 mL 0.5262 mL 1.3156 mL
H2O 15 mM 0.0351 mL 0.1754 mL 0.3508 mL 0.8771 mL
20 mM 0.0263 mL 0.1316 mL 0.2631 mL 0.6578 mL
25 mM 0.0210 mL 0.1052 mL 0.2105 mL 0.5262 mL
30 mM 0.0175 mL 0.0877 mL 0.1754 mL 0.4385 mL
40 mM 0.0132 mL 0.0658 mL 0.1316 mL 0.3289 mL
50 mM 0.0105 mL 0.0526 mL 0.1052 mL 0.2631 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Iseganan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iseganan257277-05-7IB-367IB367IB 367BacterialFungalParasiteanti-bacteria activityanti-fungi activitycysticerciInhibitorinhibitorinhibit

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