Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2623)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2336)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W169645

1,5-Hexadien-3-ol	Inhibitor
1,5-Hexadien-3-ol is a green leaf volatile (GLV) alcohol that can be found in tomato plants. 1,5-Hexadien-3-ol contributes to protection against Botrytis cinerea. 1,5-Hexadien-3-ol can be used for the research of grey mould disease.

HY-132925

Antifungal agent 16	Inhibitor
Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.

HY-147944

Antimicrobial agent-4	Inhibitor
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent. Antimicrobial agent-4 exhibits considerable activity against the microbial pathogens. Antimicrobial agent-4 delivers reliable toxicity to kill the bacteria and fungi. Antimicrobial agent-4 shows high binding energy value of −10.0 kcal/mole against the target enzyme.

HY-N12591

Iso-isariin B	Inhibitor
Iso-isariin B is an analogue of cyclocarboxyphenate, which can be used in antifungal studies.

HY-N17503

Medicagenic acid 3-O-glucoside	Inhibitor
Medicagenic acid 3-O-glucoside is a monosaccharide-chain triterpenoid saponin antifungal agent that can be isolated from the roots of Medicago sativa. Against Pyricularia oryzae, Medicagenic acid 3-O-glucoside has a MIC of 0.03 mg/mL and a MFC of 0.125 mg/mL. Medicagenic acid 3-O-glucoside alters the permeability of fungal cell membranes, causing cell rupture and inhibiting fungal growth. Medicagenic acid 3-O-glucoside can be used in studies related to rice blast.

HY-178722

Deferasirox methyl ester	Inhibitor	98.40%
Deferasirox methyl ester (compound 6a), a derivative of Deferasirox (HY-17359), is an antimicrobial agent. Deferasirox methyl ester exhibits activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger with MICs of 0.5, 4.0, 1.0, 4.0, and 2.0 μg/mL, respectively. Deferasirox methyl ester can be used for antimicrobial research.

HY-N11685

(±)-Lomatin	Inhibitor
(±)-Lomatin (Xanthogalol) (Compound 10) is a coumarin-type secondary metabolite. (±)-Lomatin can be found in Coleonema album. (±)-Lomatin can be used for the research of bacterial infections, mycobacterial infections, and fungal infections.

HY-149603

Antifungal agent 78	Inhibitor
Antifungal agent 78 (compound 25am) is an antifungal agent with an EC₅₀ value of 13.46 μM against F. graminearum.

HY-126461

Salazinic acid	Inhibitor
Salazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium.

HY-P5642

Retrocyclin-101	Inhibitor
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression.

HY-P10304D

Cyclo(Pro-dArg) acetate	Inhibitor	98.12%
Cyclo(Pro-dArg) acetate is a chitinase inhibitor. Cyclo(Pro-dArg) acetate inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) acetate inhibits the transition of Candida albicans from yeast to filamentous morphology.

HY-141812

Antifungal agent 12	Inhibitor
Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities.

HY-174973

CYP51-IN-26	Inhibitor
CYP51-IN-26 is a CYP51 inhibitor with an IC₅₀ value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections.

HY-W840250

3,5-Dimethyl-4-phenylisoxazole	Inhibitor
3,5-Dimethyl-4-phenylisoxazole (3,5-Dimethyl-4-phenyl-1,2-oxazole) is a heterocyclic compound that serves as a molecular structural unit, exhibiting anti-inflammatory, anti-tumor, anti-bacterial, and anti-fungal properties, along with the capacity to modulate the immune system.

HY-163571

CYP51-IN-17	Inhibitor
CYP51-IN-17 (compound 7a) is a potent CYP51 inhibitor with an IC₅₀ of 0.377 μg/mL. CYP51-IN-17 shows significant fungicidal activity against B. cinerea with an EC₅₀ of 0.326 μg/mL.

HY-P10538

Balteatide	Inhibitor
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candida albicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity.

HY-17594R

Oxyclozanide (Standard)	Inhibitor
Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity.

HY-128478

Sordarin	Inhibitor
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex.

HY-N11506

lsocryptomerin	Inhibitor
lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities.

HY-144643

CYP51/HDAC-IN-1	Inhibitor
CYP51/HDAC-IN-1 is a potent, orally active CYP51/HDAC dual inhibitor. CYP51/HDAC-IN-1 inhibits important virulence factors and down-regulated resistance-associated genes. CYP51/HDAC-IN-1 exhibits potent therapeutic effects for both tropical candidiasis and cryptococcal meningitis.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

559compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2623)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2623):