lsocryptomerin
lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities.
For research use only. We do not sell to patients.
- CAS No.: 20931-58-2
- Formula: C31H20O10
- Molecular Weight:552.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
lsocryptomerin suppresses lymphocyte proliferation and shows the cytotoxicity against human tumor cell lines[1].
lsocryptomerin (48 h) shows antifungal activity with MICs of both 18.11 μM against C. albicans, T. beigelii and S. cerevisiae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 20931-58-2
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Molecular Weight 552.48
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Formula C31H20O10
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SMILES
O=C1C=C(C2=CC=C(OC3=C(C4=C(C=C3OC)OC(C5=CC=C(O)C=C5)=CC4=O)O)C=C2)OC6=C1C(O)=CC(O)=C6
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. Lee J, et al. Isocryptomerin, a novel membrane-active antifungal compound from Selaginella tamariscina. Biochem Biophys Res Commun. 2009 Feb 13;379(3):676-80. [Content Brief]
[2]. Lee J, et al. Antibacterial and synergistic activity of isocryptomerin isolated from Selaginella tamariscina. J Microbiol Biotechnol. 2009 Feb;19(2):204-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
lsocryptomerin Related Classifications
HY-N11506 Related Classifications
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