2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12230
    Penicolinate B
    		Inhibitor
    Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candida albicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors.
    Penicolinate B
  • HY-N6687B
    Calcimycin hemimagnesium
    		Inhibitor
    Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy.
    Calcimycin hemimagnesium
  • HY-W540874
    1-Heptadecene
    		Inhibitor
    1-Heptadecene is a metabolite found in Aporosa cardiosperma. 1-Heptadecene has antifungal and antibacterial activities.
    1-Heptadecene
  • HY-147805
    SARS-CoV-2 3CLpro-IN-4
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
    SARS-CoV-2 3CLpro-IN-4
  • HY-183333
    CHNQD-02204
    		Inhibitor
    CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections.
    CHNQD-02204
  • HY-151566
    Antifungal agent 46
    		Inhibitor
    Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase.
    Antifungal agent 46
  • HY-148294
    Monogalactosyl diglyceride
    		Inhibitor
    Monogalactosyl diglyceride is a antimicrobial. Monogalactosyl diglyceride has antibacterial activity and antifungal activity in vitro.
    Monogalactosyl diglyceride
  • HY-162296
    Antibacterial agent 188
    		Inhibitor
    Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity.
    Antibacterial agent 188
  • HY-120183
    Harzianopyridone
    		Inhibitor
    Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities.
    Harzianopyridone
  • HY-W004282S2
    Undecanoic acid-d2
    		Inhibitor
    Undecanoic acid-d2 (Undecanoate-d2) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid-d<sub>2</sub>
  • HY-146464
    Antifungal agent 30
    		Inhibitor
    Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51.
    Antifungal agent 30
  • HY-N15263
    Cepafungin III
    		Inhibitor
    Cepafungin III is an acylpeptide antibiotic that can be isolated from the culture broth of Pseudomonas species. Cepafungin III exhibits inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice, when mixed with Cepafungin I and II.
    Cepafungin III
  • HY-154993
    Gamma-Glutamyl Transferase-IN-1
    		Inhibitor
    Gamma-Glutamyl Transferase-IN-1 (compound 4de) is a β-carboline 1-hydrazide inhibitor with antifungal and antibacterial activities, targeting to glutamyltransferase. Gamma-Glutamyl Transferase-IN-1 acts function by resulting the accumulation of reactive oxygen species, destruction of cell membranes, and dysregulation of histone acetylation.
    Gamma-Glutamyl Transferase-IN-1
  • HY-152091
    Antiproliferative agent-18
    		Inhibitor
    Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity.
    Antiproliferative agent-18
  • HY-116866
    Sclerotiorin
    		Inhibitor
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
  • HY-B0847S1
    Propiconazole-d3 nitrate
    		Inhibitor
    Propiconazole-d3 (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).
    Propiconazole-d<sub>3</sub> nitrate
  • HY-149067
    Antifungal agent 47
    		Inhibitor
    Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide.
    Antifungal agent 47
  • HY-183975
    V-ATPase-IN-2
    		Inhibitor
    V-ATPase-IN-2 is an inhibitor targeting the a-c subunits of vacuolar H+-ATPase (V-ATPase), with an EC50 of 8.449 μg/mL against Phytophthora capsici. V-ATPase-IN-2 causes significant vacuolar enlargement and ultrastructural damage in Phytophthora capsici cells, and also inhibits sporangium formation, zoospore release, and cyst germination of this pathogen. V-ATPase-IN-2 can be used in studies related to Phytophthora capsici infection.
    V-ATPase-IN-2
  • HY-P11158
    Gymnin
    		Inhibitor
    Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research.
    Gymnin
  • HY-179250
    LEX-SQ01
    		Inhibitor
    LEX-SQ01 (Compound D10) is an antifungal agent. LEX-SQ01 shows an EC50 of 1.6 μM for C. capsici. LEX-SQ01 can disrupt the cell membrane integrity of fungal. LEX-SQ01 can be used for the research of infection in crops.
    LEX-SQ01
Cat. No. Product Name / Synonyms Application Reactivity