Antiproliferative agent-18
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity.
For research use only. We do not sell to patients.
- CAS No.: 2882206-14-4
- Formula: C26H27FN2OS
- Molecular Weight:434.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Bacteria, Fungi[1]
Antiproliferative agent-18 (Compound 5k) (200 µg/ /8 mm disc; 24 h for bacteria, 48 h for fungi) displays moderate antibacterial activity (growth inhibition zones 14–17 mm) and is moderately active against the yeast-like pathogenic fungus Candida albicans (growth inhibition zone 17 mm)[1].
Antiproliferative agent-18 (0.1-100 μM; 48 h) shows anti-proliferative activity against human prostate cancer (PC-3), colorectal carcinoma (HCT-116), hepatocellular carcinoma (HepG-2), epithelioid cervical carcinoma (HeLa) and mammary gland breast cancer (MCF-7) cell lines[1].
Antiproliferative agent-18 occupies the positions of NAD cofactor and the histone deacetylase inhibitor EX527 at the active site of SIRT1 enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, HCT-116, HepG-2, HeLa and MCF-7 cells
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Concentration:0.1-100 μM
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Incubation Time:48 h
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Result:Showed anti-proliferative activity with IC50s of 9.71 ± 0.8, 6.47 ± 0.5, 11.27 ± 0.9, 7.09 ± 0.5 and 3.51 ± 0.2 μM against PC-3, HCT-116, HepG-2, HeLa and MCF-7 cells, respectively.
Chemical Information
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CAS No. 2882206-14-4
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Molecular Weight 434.57
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Formula C26H27FN2OS
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SMILES
COC1=CC=C(C2=CS/C(N2C3=CC=C(F)C=C3)=N\C45CC6CC(C5)CC(C6)C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-18 Related Classifications
HY-152091 Related Classifications
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