2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17396R
    Butenafine Hydrochloride (Standard)
    		Inhibitor
    Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV.
    Butenafine Hydrochloride (Standard)
  • HY-163397
    Antibacterial agent 196
    		Inhibitor
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-N16849
    Myristinin A
    		Inhibitor
    Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis.
    Myristinin A
  • HY-N18269
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester
    		Inhibitor
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester is an anti-fungal triterpene saponin. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester can be isolated from the aerial parts of Clematis tangutica. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester exhibits antifungal activity against fungal strains (P. avellaneum, C. glabrata, S. cerevisiae, T. beigelii), with the strongest activity against S. cerevisiae.
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester
  • HY-N0216S7
    Benzoic acid-d
    		Inhibitor
    Benzoic acid-d is the deuterium labeled Benzoic acid (HY-N0216). Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
    Benzoic acid-d
  • HY-123457
    PF-1163A
    		Inhibitor
    PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL.
    PF-1163A
  • HY-B0453R
    Econazole nitrate (Standard)
    		Inhibitor
    Econazole (nitrate) (Standard) is the analytical standard of Econazole (nitrate). This product is intended for research and analytical applications. Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.
    Econazole nitrate (Standard)
  • HY-168470
    Antifungal agent 125
    		Inhibitor
    Antifungal agent 125 (compound 4H) is a potent inhibitor of succinate dehydrogenase (SDH), with the IC50 of 3.59 μg/mL. Antifungal agent 125 exhibits fungicidal activity against Alternaria alternata.
    Antifungal agent 125
  • HY-171540
    AnCDA-IN-1
    		Inhibitor
    AnCDA-IN-1 (Compound J075-4187) is an inhibitor of chitin deacetylase (CDA) with antifungal activity. It has an IC50 of 4.24 μM against AnCDA of A. nidulans, a minimum inhibitory concentration (MIC) of 260 μg/mL against food spoilage fungi and plant pathogenic fungi, and a minimum fungicidal concentration (MFC) of 520 μg/mL. AnCDA-IN-1 can be used in the research of the antifungal field .
    AnCDA-IN-1
  • HY-113611
    SDZ89-485
    		Inhibitor
    SDZ89-485 is an orally active triazole antifungal agent. The peak concentration of SDZ89-485 is lower, but it exhibits a stronger anti-sporofungus effect in the mouse model than Fluconazole (HY-B0101) with a higher peak concentration. SDZ89-485 can be used in studies on anti-sporofungus.
    SDZ89-485
  • HY-121387
    Furmecyclox
    		Inhibitor
    Furmecyclox is an effective fungicide. Furmecyclox shows great effects against basidiomycetes.
    Furmecyclox
  • HY-139900
    Benzyl 2-hydroxy-6-methoxybenzoate
    		Inhibitor
    Benzyl 2-hydroxy-6-methoxybenzoate shows the strongest antifungal effect, with IC50 of 25–26 μg/mL for both fungal strains.
    Benzyl 2-hydroxy-6-methoxybenzoate
  • HY-145814
    HSP90-IN-9
    		Inhibitor
    HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2).
    HSP90-IN-9
  • HY-148054
    Antifungal agent 36
    		Inhibitor
    Antifungal agent 36 is a potent anti-fungal agent. Antifungal agent 36 shows anti-fungal activity for Basidiomycetes.
    Antifungal agent 36
  • HY-N7123R
    Sulfacetamide (Standard)
    		Inhibitor
    Sulfacetamide (Standard) (Sulphacetamide (Standard)) is the analytical standard of Sulfacetamide (HY-N7123). This product is intended for research and analytical applications. Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic. Sulfacetamide has antifungal and antibacterial activities. Sulfacetamide is employed as a topical formulation in various ophthalmic, dermatological, and hair solutions against bacterial infections, acne and scalp conditions. Sulfacetamide targets bacterial folic acid synthesis and is effective against various gram-positive and gram-negative bacteria. Sulfacetamide inhibits the synthesis of both dihydro-folic acid and para-aminobenzoic acid. Sulfacetamide can be used for the study of ocular infections.
    Sulfacetamide (Standard)
  • HY-151440
    Antifungal agent 42
    		Inhibitor
    Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation.
    Antifungal agent 42
  • HY-168210
    Antifungal agent 122
    		Inhibitor
    Antifungal agent 122 (compound 201) is a potent and broad-spectrum antifungal agent. Antifungal agent 122 prevents fungal phase transition and the formation of fungal biofilm. Antifungal agent 122 inhibits CYP3A4-M and CYP3A4-T enzyme activity with IC50 values of 2.11, 4.53 µM. Antifungal agent 122 shows no cytotoxicity.
    Antifungal agent 122
  • HY-144121
    Ph-Ph+
    		Inhibitor
    Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities.
    Ph-Ph+
  • HY-168108
    Antifungal agent 115
    		Inhibitor
    Antifungal agent 115 (compound 8n) is a non-competitive chitin synthase (CHS) inhibitor with an IC50 of 93 μM. Antifungal agent 115 demonstrates good selectivity and broad-spectrum antifungal activity, exhibiting significant efficacy against drug-resistant fungi. Antifungal agent 115 can be utilized in fungi infection research.
    Antifungal agent 115
  • HY-161856
    Antifungal agent 106
    		Inhibitor
    Antifungal agent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide against Monilinia fructicola. Antifungal agent 106 exhibits antifungal activity with an EC50 value of 11.8 mg/L. It affects hyphal growth by disrupting cell membrane integrity, leading to increased membrane permeability and release of intracellular electrolytes. Antifungal agent 106 can be used in research related to brown rot of stone fruits.
    Antifungal agent 106
Cat. No. Product Name / Synonyms Application Reactivity