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Cat. No.: HY-151440

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Antifungal agent 42

Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation.

For research use only. We do not sell to patients.

CAS No.: 3033703-25-9
Formula: C₂₂H₂₀Cl₂N₄Se₂
Molecular Weight:569.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antifungal agent 42 Chemical Structure

CAS No.: 3033703-25-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation^[1].

IC₅₀ & Target

CYP51^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	12.5 μM Compound: B03	Cytotoxicity against human HL-60 cells by MTT assay Cytotoxicity against human HL-60 cells by MTT assay	[PMID: 36057236]
MDA-MB-231	IC₅₀	5.5 μM Compound: B03	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 36057236]
PC-3	IC₅₀	2.91 μM Compound: B03	Cytotoxicity against human PC-3 cells by MTT assay Cytotoxicity against human PC-3 cells by MTT assay	[PMID: 36057236]

In Vitro

Antifungal agent 42 (compound B03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL^[1].
Antifungal agent 42 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb^[1].
Antifungal agent 42 (0-20 μM approximately) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC₅₀ values of 12.5, 5.5, 2.91 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3033703-25-9
Molecular Weight 569.25
Formula C₂₂H₂₀Cl₂N₄Se₂
SMILES

ClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hang Xu, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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