Ph-Ph+ 

Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities^[1].

Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) inhibits the various tumor cell proliferation in a concentration- and time-dependent manner for H22, U251MG, human neuroblastoma SH-SY5Y cell line, mouse melanoma B16 cell line, and human lung adenocarcinoma A549 cell line). , Ph-Ph+ does not affect the viabilities of human L02 cells and HUVEC cells. Under an optical microscope, Ph-Ph+-treated tumor cells shrank and exhibited apoptotic bodies. Ph-Ph+ has a selective antitumor effect through inducing cell apoptosis^[1].
Ph-Ph+ has broad-spectrum antibacterial and antifungal activities, and drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

The tumor-bearing mice were prepared using the subcutaneous transplantation mouse hepatoma H22 cell line. Ph-Ph+ (2-8 mg/kg; i.v; for 8 days) treatment reduces tumor volume and weight in a dose-dependent manner^[1].
In animal models of liver cancer with fungal infection, the Ph-Ph+ (2-8 mg/kg; i.v; once a day for 9 days) retards proliferation of hepatoma cells in tumor-bearing mice and remedies pneumonia and encephalitis caused by Cryptococcus neoformans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

361.42

C₂₄H₁₇N₄⁺

C12=C(C=CC3=C2[N+]([H][N]4=CC=CC5=C4C6=C(C=CC=N6)C=C5)=CC=C3)C=CC=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zizhen Zhao, et al.Synthesis of Hemiprotonic Phenanthroline-Phenanthroline + Compounds with both Antitumor and Antimicrobial Activity. J Med Chem. 2022 Feb 10;65(3):2532-2547.  [Content Brief]