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Cat. No.: HY-144121

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Ph-Ph+

Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities.

For research use only. We do not sell to patients.

Formula: C₂₄H₁₇N₄⁺
Molecular Weight:361.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Ph-Ph+ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities^[1].

In Vitro

Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) inhibits the various tumor cell proliferation in a concentration- and time-dependent manner for H22, U251MG, human neuroblastoma SH-SY5Y cell line, mouse melanoma B16 cell line, and human lung adenocarcinoma A549 cell line). , Ph-Ph+ does not affect the viabilities of human L02 cells and HUVEC cells. Under an optical microscope, Ph-Ph+-treated tumor cells shrank and exhibited apoptotic bodies. Ph-Ph+ has a selective antitumor effect through inducing cell apoptosis^[1].
Ph-Ph+ has broad-spectrum antibacterial and antifungal activities, and drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The tumor-bearing mice were prepared using the subcutaneous transplantation mouse hepatoma H22 cell line. Ph-Ph+ (2-8 mg/kg; i.v; for 8 days) treatment reduces tumor volume and weight in a dose-dependent manner^[1].
In animal models of liver cancer with fungal infection, the Ph-Ph+ (2-8 mg/kg; i.v; once a day for 9 days) retards proliferation of hepatoma cells in tumor-bearing mice and remedies pneumonia and encephalitis caused by Cryptococcus neoformans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 361.42
Formula C₂₄H₁₇N₄⁺
SMILES

C12=C(C=CC3=C2[N+]([H][N]4=CC=CC5=C4C6=C(C=CC=N6)C=C5)=CC=C3)C=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zizhen Zhao, et al.Synthesis of Hemiprotonic Phenanthroline-Phenanthroline + Compounds with both Antitumor and Antimicrobial Activity. J Med Chem. 2022 Feb 10;65(3):2532-2547. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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