2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131478
    Pyruvic acid semicarbazone
    		Inhibitor
    Pyruvic acid semicarbazone is an inhibitor of bacterial and fungal. Pyruvic acid semicarbazone is promising for research of anti-infective agents, cancers, and plant growth regulation.
    Pyruvic acid semicarbazone
  • HY-172523
    CDA-IN-3
    		Inhibitor
    CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .
    CDA-IN-3
  • HY-151280
    Antifungal agent 37
    		Inhibitor
    Antifungal agent 37 is a geterocyclic disulfide, with antifungal activity.
    Antifungal agent 37
  • HY-N6294
    Monocerin
    Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca.
    Monocerin
  • HY-P4370
    Hepcidin-20 (human)
    		Inhibitor
    Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains.
    Hepcidin-20 (human)
  • HY-N18128
    Hunnemanine
    		Inhibitor
    Hunnemanine is a protoberberine-type isoquinoline alkaloid with significant antifungal activity. At a concentration of 1000 ppm, Hunnemanine completely inhibits spore germination of a variety of phytopathogenic fungi, including Alternaria brassicae, Helminthosporium pennisetti, and Fusarium lini. Hunnemanine can be applied to studies on the infection mechanisms of phytopathogenic fungi and related control strategies.
    Hunnemanine
  • HY-N3739
    Diacetonamine
    Diacetonamine is a sporulation inducing factor which can be extracted from soybean curd residue.
    Diacetonamine
  • HY-N5165
    Arborcandin F
    		Inhibitor
    Arborcandin F is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC50 values of 0.012 μg/mL against both Candida albicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida.
    Arborcandin F
  • HY-151417
    Chitin synthase inhibitor 7
    		Inhibitor
    Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection.
    Chitin synthase inhibitor 7
  • HY-108385
    Ochratoxin A-D4
    Ochratoxin A-D4 (Phe-​OTA-D4) is the deuterium labeled Ochratoxin A. Ochratoxin A is an orally active food-borne mycotoxin that can cross the blood-brain barrier. Ochratoxin A is a secondary metabolite of fungi belonging to the genera Aspergillus and Penicillium, and is classified as a Group 2B carcinogen. Ochratoxin A exerts its effects through multiple pathways, including inducing oxidative stress, inhibiting mitochondrial respiration, causing oxidative DNA damage, disrupting the PPAR-γ-CD36 axis, inducing immunosuppression, generating ROS, mediating mitochondria-dependent apoptosis, inhibiting glutamate uptake, triggering demyelination and neuroinflammation, inducing DNA hypomethylation, and inhibiting cell proliferation. Ochratoxin A can induce nephrotoxicity, hepatotoxicity, immunotoxicity, and neurotoxicity, and also exhibits mutagenicity, teratogenicity, and carcinogenicity.
    Ochratoxin A-D4
  • HY-165142
    Aureonitol
    Aureonitol is a compound isolated from fungi that has anti-influenza activity by inhibiting the surface glycoprotein hemagglutinin of influenza virus and has potential value for compound development.
    Aureonitol
  • HY-125682
    Amphotericin A
    		Inhibitor
    Amphotericin A is a tetraenic polyene antifungal agent, produced in the fermentation broth of Amphotericin B (HY-B0221). Amphotericin A has a structure identical to Amphotericin B except for a single bond between carbons 28 and 29 instead of a double bond. Amphotericin A can be used for research on fungal infection.
    Amphotericin A
  • HY-N17390
    Citaldoxime
    		Inhibitor
    Citaldoxime (Compound 7) is a γ-radiation-induced antifungal stress metabolite that can be found in Citrus plants.
    Citaldoxime
  • HY-N8537R
    Enfumafungin (Standard)
    		Inhibitor
    Enfumafungin (Standard) is the analytical standard of Enfumafungin. This product is intended for research and analytical applications. Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2].
    Enfumafungin (Standard)
  • HY-156150
    CYP51/PD-L1-IN-2
    		Inhibitor
    CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
    CYP51/PD-L1-IN-2
  • HY-179212
    (±)-Coladonin
    		Inhibitor
    (±)-Coladonin (Compound (±)-12), Coumarin (HY-N0709) derivative, is an antifungal agent. (±)-Coladonin exhibits potent inhibitory effect on the plant pathogenic fungus Botrytis cinerea. (±)-Coladonin is mainly used for the research on the prevention and control of gray mold disease in crops.
    (±)-Coladonin
  • HY-121109S
    Benalaxyl-d5
    		Inhibitor
    Benalaxyl-d5 is the deuterium labeled Benalaxyl (HY-121109). Benalaxyl is a fungicide, but A. fumigatus isolates are intrinsically resistant to Benalaxyl.
    Benalaxyl-d<sub>5</sub>
  • HY-N18251
    trans-β-Bergamotene
    		Inhibitor
    trans-β-Bergamotene is a sesquiterpene hydrocarbon and antifungal agent found in the essential oil of Bixa orellana L. leaves. trans-β-Bergamotene possesses antiungal and anti-inflammatory properties. trans-β-Bergamotene can be used for the research of Candida albicans infection.
    trans-β-Bergamotene
  • HY-D0027S1
    7-Amino-4-methylcoumarin-d4
    7-Amino-4-methylcoumarin-d4 (Coumarin 120-d4) is the deuterium labeled 7-Amino-4-methylcoumarin (HY-D0027). 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
    7-Amino-4-methylcoumarin-d<sub>4</sub>
  • HY-W042181S
    N-Decyl-N,N-dimethyldecan-1-aminium-d6 chloride
    		Inhibitor
    N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride). N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties.
    N-Decyl-N,N-dimethyldecan-1-aminium-d<sub>6</sub> chloride
Cat. No. Product Name / Synonyms Application Reactivity