Amphotericin A
Amphotericin A is a tetraenic polyene antifungal agent, produced in the fermentation broth of Amphotericin B (HY-B0221). Amphotericin A has a structure identical to Amphotericin B except for a single bond between carbons 28 and 29 instead of a double bond. Amphotericin A can be used for research on fungal infection.
For research use only. We do not sell to patients.
- CAS No.: 1405-32-9
- Formula: C47H75NO17
- Molecular Weight:926.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Amphotericin A (0.35-0.80 μg/mL dissolved in DMSO; 3.5-10.1 μg/mL aqueous suspension) inhibits the growth of Candida albicans, Candida tropicalis, and Saccharomyces cerevisiae with MIC values ranging from 0.35 to 0.80 μg/mL when dissolved in DMSO, and 3.5 to 10.1 μg/mL when prepared as an aqueous suspension[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1405-32-9
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Molecular Weight 926.09
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Formula C47H75NO17
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SMILES
C[C@@H]1OC(C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Aszalos A, et al. Physico-chemical and microbiological comparison of nystatin, amphotericin A and amphotericin B, and structure of amphotericin A. J Antibiot (Tokyo). 1985;38(12):1699-1713. [Content Brief]
[2]. Sowiński P, et al. The structure of amphotericin A. II. The complete structure of the antibiotic. J Antibiot (Tokyo). 1985 Feb;38(2):175-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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