Ochratoxin A-D4
Ochratoxin A-D4 (Phe-OTA-D4) is the deuterium labeled Ochratoxin A. Ochratoxin A is an orally active food-borne mycotoxin that can cross the blood-brain barrier. Ochratoxin A is a secondary metabolite of fungi belonging to the genera Aspergillus and Penicillium, and is classified as a Group 2B carcinogen. Ochratoxin A exerts its effects through multiple pathways, including inducing oxidative stress, inhibiting mitochondrial respiration, causing oxidative DNA damage, disrupting the PPAR-γ-CD36 axis, inducing immunosuppression, generating ROS, mediating mitochondria-dependent apoptosis, inhibiting glutamate uptake, triggering demyelination and neuroinflammation, inducing DNA hypomethylation, and inhibiting cell proliferation. Ochratoxin A can induce nephrotoxicity, hepatotoxicity, immunotoxicity, and neurotoxicity, and also exhibits mutagenicity, teratogenicity, and carcinogenicity.
For research use only. We do not sell to patients.
- CAS No.: 1448049-50-0
- Formula: C20H14D4ClNO6
- Molecular Weight:407.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
0.08 μM
Compound: 2
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Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay
Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay
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[PMID: 19919898] |
| HepG2 | IC50 |
0.4 μM
Compound: 2
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Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay
Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay
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[PMID: 19919898] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1448049-50-0
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Molecular Weight 407.84
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Formula C20H14D4ClNO6
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SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC(C2=CC(Cl)=C(C3=C2O)C[C@](C([2H])([2H])[2H])([2H])OC3=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. [Content Brief]
[2]. Bouisseau A, et al. First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring. Org Lett. 2013 Aug 2;15(15):3888-90. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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