Glucosidase Inhibitor

3,5-Dihydroxybenzaldehyde is an α-glucosidase inhibitor with an IC₅₀ of 0.47 μg/mL. 3,5-Dihydroxybenzaldehyde exerts bactericidal activity against Campylobacter jejuni, Escherichia coli O157:H7, Listeria monocytogenes and Salmonella enterica. 3,5-Dihydroxybenzaldehyde can be used in glucose metabolism-related research.

Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect.

2-(2-Phenylethyl) chromone (Flidersiachromone) is a chromone derivative and antioxidant. 2-(2-Phenylethyl) chromone scavenges ABTS·⁺ free radicals, and its derivatives exhibit diverse activities including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. 2-(2-Phenylethyl) chromone is applicable to experimental research in fields such as inflammation-related diseases, tumors, and neurodegenerative diseases.

D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC₅₀ of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle.

2-Hydroxyquinoline is an α-glucosidase inhibitor (IC₅₀ = 64.4 µg/mL) and an α-amylase inhibitor (IC₅₀ = 130.5 µg/mL). 2-Hydroxyquinoline inhibits α-glucosidase and α-amylase activities. 2-Hydroxyquinoline exhibits antidiabetic effects. 2-Hydroxyquinoline can be used for research on diabetes.

Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity.

Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects.

Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC₅₀ of 68.33 μM, and tyrosinase with an IC₅₀ of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation.

trans-2-Methoxycinnamic acid (Compound 6) is a trans-cinnamic acid (HY-N0610) derivative. trans-2-Methoxycinnamic acid inhibits α-glucosidase with an IC₅₀ of 4.34 mM. trans-2-Methoxycinnamic acid can be used in the research of HIV infection and hyperglycemia.

α-Glucosidase-IN-22 (Compound 7i) is a α-glucosidase inhibitor with an IC₅₀ value of 0.64 μM. α-Glucosidase-IN-22 can be used for the research of type 2 diabetes.

D-Threitol (Standard) is the analytical standard of D-Threitol (HY-W012846). This product is intended for research and analytical applications. D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC₅₀ of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle.

Millewanin H is a Flavonoids product that can be isolated from the herbs of Millettia pachycarpa. Millewanin H has antiestrogenic activity and inhibit 17β-estradiol-induced-β-galactosidase activity. Millewanin H showes α-glucosidase inhibition.

trans-p-Coumaraldehyde ((E)-4-Hydroxycinnamaldehyde) is a natural product. trans-p-Coumaraldehyde can be isolated from the seeds of Petai cina. trans-p-Coumaraldehyde exhibits potential α-glucosidase inhibitory activity. trans-p-Coumaraldehyde can be used in diabetes research.

Ceftezole (GR69153) is a broad-spectrum cephalosporin antibiotic and an α-glucosidase inhibitor. Ceftezole inhibits bacterial cell lysis by inhibiting cell wall synthesis and binding to penicillin-binding proteins (PBPs). Ceftezole exhibits in vivo anti-diabetic activity in diabetic mice. Ceftezole can be used in antibacterial and anti-diabetic research.

α-Glucosidase-IN-78 (Compound 12m) is an inhibitor for α-glucosidase with a reversible, competitive IC₅₀ 6.0 μM. α-Glucosidase-IN-78 can be used in research of diabete for its hypoglycemic property.

ALR2/α-Glucosidase-IN-1 (Compound 4) is a competitive ALR2 inhibitor and competitive α-glucosidase inhibitor, with an IC₅₀ of 0.250 μM against ALR2 and an IC₅₀ of 0.561 μM against α-glucosidase. ALR2/α-Glucosidase-IN-1 binds to the active sites of ALR2 and α-glucosidase, and inhibits enzymatic activity by competing with their respective substrates. ALR2/α-Glucosidase-IN-1 can be used in diabetes-related research.

α-Glucosidase-IN-95 (Compound 21c) is a competitive α-Glucosidase inhibitor with an IC₅₀ of 0.44  μM. α-Glucosidase-IN-95 has a significant inhibitory potency without cytotoxicity to normal cells. α-Glucosidase-IN-95 can be used for metabolic disorders like diabetes mellitus research.

Euphominoid C is a competitive α-glucosidase inhibitor (IC₅₀ = 52.50 μM) and a mixed-type β-glucuronidase inhibitor (IC₅₀ = 45.87 μM). Euphominoid C exhibits reversible binding modes against both enzymes. Euphominoid C can be used for the research of diabetes.

α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-Glucosidase, with the IC₅₀ of 13.66 μM. α-Glucosidase-IN-82 exhibits a 52-fold increase in inhibitory activity relative to Acarbose (HY-B0089).

α-Glucosidase-IN-101 (Compound 13j) is an uncompetitive α-glucosidase inhibitor, with an IC₅₀ of 120 nM. α-Glucosidase-IN-101 properly inhibits CYP1A2, CYP2C19, and CYP2C9 isoforms of cytochrome P450. α-Glucosidase-IN-101 can be used in the research of diabetes.