2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W017613
    (Ethoxymethyl)benzene
    		98.99%
    (Ethoxymethyl)benzene is an endogenous metabolite.
    (Ethoxymethyl)benzene
  • HY-W007376S
    Indole-3-carboxaldehyde-13C3
    Indole-3-carboxaldehyde-13C (3-Formylindole-13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin.
    Indole-3-carboxaldehyde-<sup>13</sup>C<sub>3</sub>
  • HY-P2871B
    α1-3,4,6 Galactosidase
    α1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing α1-3, α1-4 and α1-6-linked galactose residues from oligosaccharides.
    α1-3,4,6 Galactosidase
  • HY-107372
    Uridine triphosphate
    Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.
    Uridine triphosphate
  • HY-P4550
    H-Hyp-Gly-OH
    		98.28%
    H-Hyp-Gly-OH is a dipeptide containing hydroxyproline and glycine. H-Hyp-Gly-OH promotes the growth of mouse primary fibroblasts on collagen gel. H-Hyp-Gly-OH has potential applications in improving skin by ingesting hydrolyzed collagen. H-Hyp-Gly-OH can be used for metabolic research.
    H-Hyp-Gly-OH
  • HY-B1674
    (±)-Leucine
    		99.95%
    (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%.
    (±)-Leucine
  • HY-N0394S2
    L-Cystine-15N2
    		99.27%
    L-Cystine-15N2 is the 15N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.
    L-Cystine-<sup>15</sup>N<sub>2</sub>
  • HY-113274A
    Pi-Methylimidazoleacetic acid hydrochloride
    		99.01%
    Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.
    Pi-Methylimidazoleacetic acid hydrochloride
  • HY-N7122A
    Thymopentin acetate
    		99.95%
    Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs).
    Thymopentin acetate
  • HY-N0304S1
    L-DOPA-13C6
    		99.11%
    L-DOPA-13C6 is the 13C-labled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA-<sup>13</sup>C<sub>6</sub>
  • HY-W019833
    MSPC
    		≥99.0%
    MSPC is an asymmetrical phosphatidylcholine containing a myristic acid (14:0) at the sn-1 position and a stearic acid (18:0) at the sn-2 position. It can self assemble in water to form lipid bilayers. Reagent grade, for research purpose.
    MSPC
  • HY-B0152S
    Adenine-d
    		Chemical 99.91%
    Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
    Adenine-d
  • HY-P2808
    4-Phytase
    4-Phytase is a phosphohydrolase of inositol hexaphosphate.
    4-Phytase
  • HY-N0229S9
    L-Alanine-13C2
    		99.97%
    L-Alanine-13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-<sup>13</sup>C<sub>2</sub>
  • HY-N2854
    α-Viniferin
    		99.43%
    α-Viniferin is an anti-inflammatory compound from Caragana chamlagu root.
    α-Viniferin
  • HY-Y1804
    D-Lysine monohydrochloride
    		99.72%
    D-Lysine monohydrochloride is an Lysine stereoisomer which can be used as a component of surfactants.
    D-Lysine monohydrochloride
  • HY-W008559
    L-Tyrosinamide
    		98.95%
    L-Tyrosinamide is a derivative of Tyrosine, is an amino acid amide.
    L-Tyrosinamide
  • HY-165136
    Sphingomyelins, milk
    		99.20%
    Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes.
    Sphingomyelins, milk
  • HY-E70032
    N-Acetylhexosamine kinase (NahK)
    N-Acetylhexosamine kinase (NahK) is an anomeric kinase acting on a glucose-type substrate. N-Acetylhexosamine kinase catalyzes the phosphorylation of GlcNAc or GalNAc at the anomeric C1 position with ATP to form N-acetylhexosamine 1-phosphate (GlcNAc-1P/GalNAc-1P).
    N-Acetylhexosamine kinase (NahK)
  • HY-W653733
    L-Homocysteine-d4
    L-Homocysteine-d4 is deuterium labeled L-Homocysteine (HY-W010347). L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia
    L-Homocysteine-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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