2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

Related Products

PDF 48.35 MB

Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0643R
    Carnosol (Standard)
    Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1).
    Carnosol (Standard)
  • HY-115684R
    2-Undecanol (Standard)
    Pyraoxystrobin (Standard) is the analytical standard of Pyraoxystrobin. This product is intended for research and analytical applications. Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
    2-Undecanol (Standard)
  • HY-N0210S1
    D-Galactose-13C-2
    		99.9%
    D-Galactose-13C-2 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
    D-Galactose-<sup>13</sup>C-2
  • HY-W046906R
    (E)-Oct-2-enoic acid (Standard)
    Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities.
    (E)-Oct-2-enoic acid (Standard)
  • HY-N7127R
    (E)-m-Coumaric acid (Standard)
    (E)-m-Coumaric acid (Standard) is the analytical standard of (E)-m-Coumaric acid. This product is intended for research and analytical applications. (E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an aromatic acid that highly abundant in food. (E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an antioxidant.
    (E)-m-Coumaric acid (Standard)
  • HY-B0152AR
    Adenine hydrochloride (Standard)
    Adenine (hydrochloride) (Standard) is the analytical standard of Adenine (hydrochloride). This product is intended for research and analytical applications. Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
    Adenine hydrochloride (Standard)
  • HY-18733S
    Lipoic acid-d4
    Lipoic acid-d4 ((R)-(+)-α-Lipoic acid-d4) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
    Lipoic acid-d<sub>4</sub>
  • HY-W001959R
    D-Allothreonine (Standard)
    D-Allothreonine (Standard) is an analytical standard for D-Allothreonine (HY-001959). This product is intended for research and analytical applications. D-Allothreonine is the D-stereoisomer of allothreonine. D-Allothreonine is a bacterial peptide lipid. D-Allothreonine is specifically oxidized by D-amino acid oxidase, while the L-form is unresponsive. D-Allothreonine is also a component of bacterial polysaccharides. D-Allothreonine can be used to study bacterial pathogenicity, antigenic diversity, and drug resistance.
    D-Allothreonine (Standard)
  • HY-W008449R
    1-Methylxanthine (Standard)
    1-Methylxanthine (Standard) is the analytical standard of 1-Methylxanthine. This product is intended for research and analytical applications. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine (Standard)
  • HY-15398S4
    Vitamin D3-13C5
    Vitamin D3-13C5 is the 13C-labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    Vitamin D3-<sup>13</sup>C<sub>5</sub>
  • HY-Y0479S3
    L-Lactic acid-2-13C1
    L-Lactic acid-2-13C1 is the 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.
    L-Lactic acid-2-<sup>13</sup>C<sub>1</sub>
  • HY-Y1055S4
    Guanine-13C5
    Guanine-13C5 is 13C-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.
    Guanine-<sup>13</sup>C<sub>5</sub>
  • HY-N0457AR
    L-Chicoric Acid (Standard)
    L-Chicoric Acid (Standard) is the analytical standard of L-Chicoric Acid. This product is intended for research and analytical applications. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.
    L-Chicoric Acid (Standard)
  • HY-75342S
    Methyl vanillate-d3
    Methyl vanillate-d3 is deuterated labeled Methyl vanillate (HY-75342). Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
    Methyl vanillate-d<sub>3</sub>
  • HY-N0455AS11
    L-Arginine-13C6,d14 hydrochloride
    L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with 13C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator.
    L-Arginine-<sup>13</sup>C<sub>6</sub>,d<sub>14</sub> hydrochloride
  • HY-B1331R
    Cyromazine (Standard)
    Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats.
    Cyromazine (Standard)
  • HY-125818S2
    Cytidine-5'-triphosphate-13C,d1 dilithium
    Cytidine-5'-triphosphate-13C,d1 (Cytidine triphosphate-13C,d1 dilithium; 5'-CTP-13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-<sup>13</sup>C,d<sup>1</sup> dilithium
  • HY-15097S
    Myricetin-13C3
    Myricetin-13C3 is the 13C-labeled Myricetin. Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
    Myricetin-<sup>13</sup>C<sub>3</sub>
  • HY-129459R
    α-Tocotrienol (Standard)
    α-Tocotrienol (Standard) is the analytical standard of α-Tocotrienol. This product is intended for research and analytical applications. α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.
    α-Tocotrienol (Standard)
  • HY-W272217R
    Octacosane (Standard)
    Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l.
    Octacosane (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.