2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W724350
    2,3,5-Trimethylpyrazine-d10
    2,3,5-Trimethylpyrazine-d10 is the deuterium labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d<sub>10</sub>
  • HY-158873
    N,N-Dihexyl sphingosine (d18:1/6:0/6:0)
    N,N-Dihexyl sphingosine (d18:1/6:0/6:0) (N,N-Dihexyl-D-erythro-sphingosine) is a synthetic analog of C18-Ceramide (HY-100355).
    N,N-Dihexyl sphingosine (d18:1/6:0/6:0)
  • HY-167938
    (E/Z)-PG-11047
    (E/Z)-PG-11047 ((E/Z)-CGC-11047) is a polyamine analog with potential application in lung cancer inhibition. (E/Z)-PG-11047 effectively inhibited the growth of non-small cell and small cell lung cancer cells. (E/Z)-PG-11047 exhibits significant biochemical effects in non-small cell lung cancer cells, resulting in significant downregulation of polyamine synthetase activity. (E/Z)-PG-11047 induces polyamine metabolism, resulting in a significant reduction in polyamine levels.
    (E/Z)-PG-11047
  • HY-E70961A
    γ-Glutamyltranspeptidase, Equine
    γ-Glutamyltranspeptidase, Equine (EC 2.3.2.2) is an enzyme capable of transferring the γ-glutamyl functional group. γ-Glutamyltranspeptidase, Equine (EC 2.3.2.2) catalyzes the transfer of the γ-glutamyl group of glutathione to a receptor, which can be an amino acid, peptide, or water (to produce glutamate).
    γ-Glutamyltranspeptidase, Equine
  • HY-113442
    6-trans-12-epi-Leukotriene B4
    6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.
    6-trans-12-epi-Leukotriene B4
  • HY-W008449S2
    1-Methylxanthine-d3
    1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine-d<sub>3</sub>
  • HY-D0186S5
    2'-Deoxyuridine-d
    2'-Deoxyuridine-d is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud<
    2'-Deoxyuridine-d
  • HY-N7092S3
    D-Fructose-13C2
    		98.0%
    D-Fructose-13C2 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
    D-Fructose-<sup>13</sup>C<sub>2</sub>
  • HY-113239S1
    rel-Hydroxycotinine-d3
    rel-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    rel-Hydroxycotinine-d<sub>3</sub>
  • HY-100981
    MR-16728 hydrochloride
    MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins.
    MR-16728 hydrochloride
  • HY-P2848C
    Cholesterol Oxidase, Pseudomonas sp.
    Cholesterol Oxidase, Pseudomonas sp. (EC 1.1.3.6) belongs to the oxidoreductase family, acts on the CH-OH group of the donor molecule, and uses oxygen as the acceptor. Cholesterol Oxidase, Pseudomonas sp. (EC 1.1.3.6) participates in the biosynthesis of bile acids.
    Cholesterol Oxidase, Pseudomonas sp.
  • HY-129953B
    15(R)-Prostaglandin F2α
    15(R)-Prostaglandin F2α is the isomer of 9α,11β-Prostaglandin F2α (HY-129953). 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma.
    15(R)-Prostaglandin F2α
  • HY-41700R
    D-Alanine (Standard)
    D-Alanine (Standard) is the analytical standard of D-Alanine. This product is intended for research and analytical applications. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
    D-Alanine (Standard)
  • HY-I0746S
    3-Aminobenzoic acid-d4
    3-Aminobenzoic acid-d4 is the deuterium labeled 3-Aminobenzoic acid.
    3-Aminobenzoic acid-d<sub>4</sub>
  • HY-W654234
    Hydroxyphenyllactic acid-d3
    Hydroxyphenyllactic acid-d3 is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid-d<sub>3</sub>
  • HY-N10270
    Verrucofortine
    Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine.
    Verrucofortine
  • HY-W012814S1
    4-Methylcatechol-d8
    4-Methylcatechol-d8 is the deuterium labeled 4-Methylcatechol. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase.
    4-Methylcatechol-d<sub>8</sub>
  • HY-N15254
    2-S-Cysteinyldopa
    2-S-Cysteinyldopa is a cross-linking compound that can be isolated from the byssal threads of P. canaliculus. 2-S-Cysteinyldopa also can be formed by oxidation of pcfp-1 in vitro using mushroom tyrosinase.
    2-S-Cysteinyldopa
  • HY-N0215S9
    L-Phenylalanine-13C9,15N,d8
    L-Phenylalanine-13C9,15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N,d<sub>8</sub>
  • HY-160755
    UM-2
    UM-2 is the urinary 3-hydroxy metabolite of DX-8951 (HY-13631) in human.
    UM-2
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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