2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W010224R
    3-Amino-4-hydroxybenzoic acid (Standard)
    Vasicine (hydrochloride) (Standard) is the analytical standard of Vasicine (hydrochloride). This product is intended for research and analytical applications. Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.
    3-Amino-4-hydroxybenzoic acid (Standard)
  • HY-15127S
    Isotretinoin-d5
    Isotretinoin-d5 is the deuterium labeled Isotretinoin. Isotretinoin is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity.
    Isotretinoin-d<sub>5</sub>
  • HY-N8606
    N-Acetylciprofloxacin
    N-Acetylciprofloxacin is the metabolite of Ciprofloxacin (HY-B0356).
    N-Acetylciprofloxacin
  • HY-13715S
    (Rac)-Norepinephrine-d3 formate
    (Rac)-Norepinephrine-d3 (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
    (Rac)-Norepinephrine-d<sub>3</sub> formate
  • HY-W741191
    (2E,13Z)-Octadecadienal
    (2E,13Z)-Octadecadienal is an insect sex pheromone capable of attracting clearwing moths (Synanthedon tipulformis (Clerck)) or raspberry crown borers (Pennisetia marginata (Harris))). (2E,13Z)-Octadecadienal can be isolated from (2E,13Z)-Octadecadienyl acetate, which induces strong responses in male antennae.
    (2E,13Z)-Octadecadienal
  • HY-N6685R
    3-Acetyldeoxynivalenol (Standard)
    3-Acetyldeoxynivalenol (3-AcDON; 3ADON) (Standard) is the analytical standard of 3-Acetyldeoxynivalenol (HY-N6685). This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells.
    3-Acetyldeoxynivalenol (Standard)
  • HY-F0003AR
    NADPH tetracyclohexanamine (Standard)
    NADPH (tetracyclohexanamine) (Standard) is the analytical standard of NADPH (tetracyclohexanamine). This product is intended for research and analytical applications. 0
    NADPH tetracyclohexanamine (Standard)
  • HY-N9371R
    Crocin IV (Standard)
    Crocin IV (Standard) is the analytical standard of Crocin IV. This product is intended for research and analytical applications. Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity.
    Crocin IV (Standard)
  • HY-W015824S6
    L-Aspartic acid-13C-1
    L-Aspartic acid-13C-2 is the 13C-labeled L-Aspartic acid (HY-N0666). L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions.
    L-Aspartic acid-<sup>13</sup>C-1
  • HY-W615108BR
    β-Nicotinamide mononucleotide, reduced form disodium (Standard)
    β-Nicotinamide mononucleotide, reduced form (disodium) (Standard) is the analytical standard of β-Nicotinamide mononucleotide, reduced form (disodium) (HY-W615108B). This product is intended for research and analytical applications. β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).
    β-Nicotinamide mononucleotide, reduced form disodium (Standard)
  • HY-128735R
    N-Formylglycine (Standard)
    N-Formylglycine (Standard) is the analytical standard of N-Formylglycine. This product is intended for research and analytical applications. N-Formylglycine is an endogenous metabolite.
    N-Formylglycine (Standard)
  • HY-Y0068R
    N-Acetyl-L-phenylalanine (Standard)
    N-Acetyl-L-phenylalanine (Standard) is the analytical standard of N-Acetyl-L-phenylalanine. This product is intended for research and analytical applications. N-Acetyl-L-phenylalanine (N-Acetylphenylalanine), the principal acylamino acid in Escherichia coli, is synthesized from L-phenylalanine and acetyl-CoA.
    N-Acetyl-L-phenylalanine (Standard)
  • HY-W007355S2
    Skatole-13C6
    Skatole-13C6 is the 13C-labeled Skatole (HY-W007355). Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream.
    Skatole-13C<sub>6</sub>
  • HY-W339816
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium
  • HY-151994S
    1,3-Diolein-d66
    1,3-Diolein-d66 is deuterium labeled 1,3-Diolein. 1,3-Diolein is a phospholipid compound that has the activity of regulating cell membrane fluidity and signal transduction. 1,3-Diolein is widely used in cell biology research to study lipid-mediated signal transduction pathways and membrane protein interactions. 1,3-Diolein can also serve as a functional carrier in compound delivery systems to help improve the bioavailability of compounds.
    1,3-Diolein-d<sub>66</sub>
  • HY-W017007R
    3-Methyl-L-histidine (Standard)
    3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin.
    3-Methyl-L-histidine (Standard)
  • HY-W004924R
    5-Hydroxymethyluracil (Standard)
    5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
    5-Hydroxymethyluracil (Standard)
  • HY-B0275R
    Oxytetracycline (Standard)
    Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity.
    Oxytetracycline (Standard)
  • HY-139101
    Guanosine 5'-triphosphate-5'-adenosine
    Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog.
    Guanosine 5'-triphosphate-5'-adenosine
  • HY-101240
    Propranolol glycol
    		99.30%
    Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity.
    Propranolol glycol
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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