Trypanosoma Inhibitor

Trypanosoma Inhibitors (68):

Cat. No.	Nombre del producto	Efecto	Pureza

HY-151942

Antitrypanosomal agent 10	Inhibitor
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits *Trypanosoma cruzi* with an IC₅₀ of 0.28 μM.

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Inhibitor
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana.

HY-121405

Malonomicin	Inhibitor
Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo.

HY-N11550

Salviandulin E	Inhibitor
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC₅₀ value of 0.72 µg/mL.

HY-151485

Anti-infective agent 5	Inhibitor
Anti-infective agent 5 (compound 74) is an orally active inhibitor of *Trypanosoma cruzi* with an IC₅₀ value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.

HY-N2656

5,7,8-Trimethoxycoumarin	Inhibitor
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.

HY-124623

DNDI-8219	Inhibitor
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-W040073S

Nifurtimox-d₄	Inhibitor
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-N2392S

Kukoamine A-d₈ dihydrochloride	Inhibitor
Kukoamine A-d₈ (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity.

HY-149078

Antiparasitic agent-14	Inhibitor
Antiparasitic agent-14 is a potent antiparasitic agent. Antiparasitic agent-14 shows cytotoxicity and antiparasitic activity. Antiparasitic agent-14 inhibits the growth of trypomastigote and amastigote.

HY-151943

Antitrypanosomal agent 11	Inhibitor
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits *Trypanosoma cruzi* with an IC₅₀ of 0.23 μM.

HY-115971

Anti-Trypanosoma cruzi agent-1	Inhibitor
Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity.

HY-125648

Euphorbadienol	Inhibitor
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity.

HY-148323

Anti-Trypanosoma cruzi agent-4	Inhibitor
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection.

HY-149079

Antiparasitic agent-15	Inhibitor
Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC₅₀s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC₅₀s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes.

HY-N8257

Dehydrobruceine A	Inhibitor
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum.

HY-118965

Alazopeptin	Inhibitor
Alazopeptin is a non-ribosomal tripeptide azoamino acid antibiotic isolated from various Streptomyces species, with significant anti-tumor, antibacterial and trypanocidal activities. Alazopeptin exhibits cytotoxicity against mouse leukemia cells and S-180 tumor cells, inhibits the growth of Bacillus subtilis, and shows activity against Trypanosoma brucei. Alazopeptin can be widely used in studies related to mouse leukemia, S-180 tumor, human African trypanosomiasis and nagana.

HY-146041

Antiparasitic agent-2	Inhibitor
Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC₅₀s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC₅₀ = 26.79 μM).

HY-112252

MDL 73811	Inhibitor
MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT.

HY-147549

Antitrypanosomal agent 6	Inhibitor
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against *Trypanosoma brucei* (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA.

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