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Cat. No.: HY-151942

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Antitrypanosomal agent 10

Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM.

For research use only. We do not sell to patients.

Formula: C₁₇H₉F₆N₅O
Molecular Weight:413.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Antitrypanosomal agent 10 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM^[1].

IC₅₀ & Target

Trypanosoma

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	2.4 μM Compound: 46	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
L6	CC₅₀	50 μM Compound: 46	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
MRC5	CC₅₀	>64 μM Compound: 46	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
NIH3T3	CC₅₀	>40 μM Compound: 46	Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
Peritoneal macrophage	CC₅₀	4 μM Compound: 46	Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]

In Vitro

Antitrypanosomal agent 10 (compound 46) has good selectivity over mammalian cells, acceptable mouse liver microsome (MLM) clearance and lipophilicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 413.28
Formula C₁₇H₉F₆N₅O
SMILES

N#CC1=CC=C2N=C(N(C2=C1)CC(F)(F)F)NC(C3=CC=NC(C(F)(F)F)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Celso de Oliveira Rezende Júnior, et al. Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease.Eur J Med Chem. 2022 Nov 15;246:114925. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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