2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1117
    Tristin
    		Inhibitor 99.26%
    Tristin is a PTP1B inhibitor (IC50=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses.
    Tristin
  • HY-112139
    4-(Bromoacetyl)phenoxyacetic acid
    		Inhibitor
    4-(Bromoacetyl)phenoxyacetic acid (PTP inhibitor III) is a protein tyrosine phosphatase (PTP) inhibitor.
    4-(Bromoacetyl)phenoxyacetic acid
  • HY-18956A
    (E/Z)-Icerguastat hydrochloride
    		Inhibitor
    (E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains.
    (E/Z)-Icerguastat hydrochloride
  • HY-N15308
    Kanjone
    		Inhibitor
    Kanjone is a compound found in Millettia peguensis and can be used for the synthesis of protein tyrosine phosphatase 1B (PTP1B) inhibitors. Kanjone holds promise for research in the fields of diabetes and neurological disorders.
    Kanjone
  • HY-103060R
    KLH45 (Standard)
    		Inhibitor
    KLH45 (Standard) is the analytical standard of KLH45 (HY-103060). This product is intended for research and analytical applications. KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.
    KLH45 (Standard)
  • HY-N2451R
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
    		Inhibitor
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
  • HY-180456
    Phosphatase-IN-2
    		Inhibitor
    Phosphatase-IN-2 (Compound 26) is a CpxA phosphatase inhibitor. Phosphatase-IN-2 can be used in the research of Escherichia coli infection.
    Phosphatase-IN-2
  • HY-101510R
    F1063-0967 (Standard)
    		Inhibitor
    F1063-0967 (Standard) is the analytical standard of F1063-0967 (HY-101510). This product is intended for research and analytical applications. F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
    F1063-0967 (Standard)
  • HY-101972R
    AZ-PFKFB3-67 (Standard)
    		Inhibitor
    AZ-PFKFB3-67 (Standard) is the analytical standard of AZ-PFKFB3-67 (HY-101972). This product is intended for research and analytical applications. AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity.
    AZ-PFKFB3-67 (Standard)
  • HY-108543R
    NSC 95397 (Standard)
    		Inhibitor
    NSC 95397 (Standard) is the analytical standard of NSC 95397 (HY-108543). This product is intended for research and analytical applications. NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)). NSC 95397 inhibits mitogen-activated protein Kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
    NSC 95397 (Standard)
  • HY-112554
    PDM11
    		Inhibitor 99.93%
    PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays.
    PDM11
  • HY-N12736
    Dehydrodanshenol A
    		Inhibitor
    Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research.
    Dehydrodanshenol A
  • HY-103693R
    NAZ2329 (Standard)
    		Inhibitor
    NAZ2329 (Standard) is the analytical standard of NAZ2329 (HY-103693). This product is intended for research and analytical applications. NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties.
    NAZ2329 (Standard)
  • HY-183688
    MptpB-IN-3
    		Inhibitor
    MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research.
    MptpB-IN-3
  • HY-10704R
    PTP1B-IN-1 (Standard)
    		Inhibitor
    PTP1B-IN-1 (Standard) (PTP1B inhibitor (Standard)) is the analytical standard of PTP1B-IN-1 (HY-10704). This product is intended for research and analytical applications. PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues.
    PTP1B-IN-1 (Standard)
  • HY-N14549
    Cycloepoxydon
    		Inhibitor
    Cycloepoxydon inhibits the Phorbol 12-myristate 13-acetate (HY-18739) (PMA)-induced NF-KB and AP-1 mediated secreted alkaline phosphatase (SEAP) expression with IC50s of 1-2 μg/mL (4.2-8.4 μM) and 3-5 μg/mL (12.6-21 μM), respectively.
    Cycloepoxydon
  • HY-109041R
    Razuprotafib (Standard)
    		Inhibitor
    Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM).
    Razuprotafib (Standard)
  • HY-164425
    ENT-03
    		Inhibitor
    ENT-03 is a centrally acting mammalian aminosterol. ENT-03 upregulates cFos activation, inhibits PTP1b and induces phosphorylation of STAT3. ENT-03 normalizes blood glucose, induces weight loss. ENT-03 can be used in the research of type 2 diabetes and obesity.
    ENT-03
  • HY-N7165
    3-O-cis-p-Coumaroyl maslinic acid
    		Inhibitor
    3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts.
    3-O-cis-p-Coumaroyl maslinic acid
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity