Tristin 

Tristin is a PTP1B inhibitor (IC₅₀=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses^[1][2][3].

Tristin exhibits broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM^[2].
Tristin is inactive against HeLa, MCF-7, and A549 cancer cell lines with an IC₅₀ value greater than 10 μM^[2].
Tristin inhibits the proliferation of human HL-60 leukemia cells with an IC₅₀ of 29 μM and human THP-1 leukemia cells with an IC₅₀ of 13 μM^[3].
Tristin (25 μM) inhibits NO production in LPS-stimulated RAW264.7 macrophages by 27.23%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

260.29

C₁₅H₁₆O₄

139101-67-0

Solid

OC1=CC(CCC2=CC=C(O)C(OC)=C2)=CC(O)=C1

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. ONO M, et al. Antioxidative constituents from Dendrobii Herba (stems of Dendrobium spp.)[J]. Food Science and Technology International, Tokyo, 1995, 1(2): 115-120.

  [2]. Zhou XM, et al. Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile. J Nat Prod. 2016;79(7):1791-1797.  [Content Brief]

  [3]. He L, et al. Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species. Eur J Med Chem. 2020;204:112530.  [Content Brief]