2. シグナル伝達
  3. Anti-infection
  4. RSV

RSV

Respiratory syncytial virus

RSV

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RSV (Respiratory syncytial virus) is a leading cause of acute respiratory infections. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination. There is a single RSV serotype with two major antigenic subgroups, A and B.

RSV is a non-segmented negative-sense single-stranded enveloped RNA virus that belongs to the family of Paramyxoviridae, genus Pneumovirus, subfamily Pneumovirinae. Its 10 genes encode 11 proteins since two overlapping open reading frames in the M2 mRNA yield two distinct matrix proteins, M2-1 and M2-2. The viral envelope contains three proteins, the G glycoprotein, the fusion (F) glycoprotein, and the small hydrophobic (SH) protein. The RSV virus comprises five other structural proteins, the large (L) protein, nucleocapsid (N), phosphoprotein (P), matrix (M), and M2-1, and two non-structural proteins (NS1 and NS2).

製品番号 製品名 製品効果 純度 構造式
  • HY-150547
    RSV-IN-6 Inhibitor
    RSV-IN-6 (Compound 53) is an anti-RSV agent targeting M2-1 protein with EC50 values of 4.4 μM and 1.3 μM against RSV-A and RSV-B strain, respectively.
    RSV-IN-6
  • HY-W013605AR
    4-Methoxycinnamaldehyde (Standard) Inhibitor
    4-Methoxycinnamaldehyde (Standard) is the analytical standard of 4-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].
    4-Methoxycinnamaldehyde (Standard)
  • HY-154968
    RSV L-protein-IN-5 Inhibitor
    RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection.
    RSV L-protein-IN-5
  • HY-146108
    RSV-IN-5 Inhibitor
    RSV-IN-5 (Compound 4) is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. RSV-IN-5 exhibits potent anti-RSV activities against not only wild-type A2 F protein (EC50=2.0 nM), but also D486N-mutant F protein (EC50=8.1 nM).
    RSV-IN-5
  • HY-N10920
    Genkwanol C Inhibitor
    Genkwanol C, a biflavonoid, has effective antiviral activity against respiratory syncytial virus (RSV) in vitro.
    Genkwanol C
  • HY-168889
    HRSV/hCoV-229E-IN-1 Inhibitor
    HRSV/hCoV-229E-IN-1 (compound 8X) is a potent HRSV and hCoV-229E inhibitor with an IC50 value of 2.1 µM for hCoV-229E. HRSV/hCoV-229E-IN-1 inhibits cell viability.
    HRSV/hCoV-229E-IN-1
  • HY-159843
    Glasmacinal Inhibitor
    Glasmacinal is a non-antibacterial macrolide agent with anti-inflammatory activity.
    Glasmacinal
  • HY-P992301
    Anti-RSV F Antibody (R4.C6) Inhibitor
    Anti-RSV F Antibody (R4.C6) is a monoclonal antibody against RSV F, with a Kd of 0.34 nM for the post-fusion RSV F trimer. Anti-RSV F Antibody (R4.C6) recognizes a unique neutralizing epitope spanning epitopes II and IV on both pre-fusion and post-fusion RSV F. Anti-RSV F Antibody (R4.C6) can be used in studies related to respiratory syncytial virus infection.
    Anti-RSV F Antibody (R4.C6)
  • HY-N0662R
    Amentoflavone (Standard) Inhibitor
    Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase.
    Amentoflavone (Standard)
  • HY-161877
    GS-7682 Inhibitor
    GS-7682 is an antiviral compound. GS-7682 has inhibitory activity against pneumoviruses and picornaviruses. GS-7682 can be used in the study of respiratory diseases such as asthma and chronic obstructive pulmonary disease.
    GS-7682
  • HY-P991495
    VIR-8190 Inhibitor
    VIR-8190 is a human IgG1 monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. VIR-8190 can be used in respiratory syncytial virus (RSV) and metapneumovirus infections research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    VIR-8190
  • HY-N9574
    Oleoside dimethylester Inhibitor
    Oleoside dimethylester is a secoiridoid glucoside found in the fruits of Ligustrum lucidum. Oleoside dimethylester exhibits inhibitory activity against type 3 parainfluenza virus (Para 3) and respiratory syncytial virus (RSV), with IC50 values of 20.8 and 83.2 μg/mL. Oleoside dimethylester also shows antioxidant effect.
    Oleoside dimethylester
  • HY-163568
    RSV-IN-11 Inhibitor
    RSV-IN-11 (compound 10b) shows antiviral activity against RSV with the IC50 of 6.32 μM. RSV-IN-10 can be used for study of respiratory infection.
    RSV-IN-11
  • HY-P991497
    ASN-500 Inhibitor
    ASN-500 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. ASN-500 can be used in respiratory syncytial virus infection research.
    ASN-500
  • HY-163773
    JNJ-7950 99.88%
    JNJ-7950 (compound 5c) exhibits antiviral activity against RSV with an EC50 value of 0.78 nM. JNJ-7950 can be used in the study of respiratory tract infections.
    JNJ-7950
  • HY-N3811
    ent-11β-Hydroxyatis-16-ene-3,14-dione Inhibitor
    ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity.
    ent-11β-Hydroxyatis-16-ene-3,14-dione
  • HY-153758
    Antiviral agent 30 Inhibitor
    Antiviral agent 30 (Example 118) is an antiviral agent. Antiviral agent 30 is active against HCV and RSV (IC50: > 25μM).
    Antiviral agent 30
  • HY-N1522
    Rengynic acid Inhibitor
    Rengynic acid can be isolated from the seeds of Forsythia suspensa. Rengynic acid has potent antiviral effect on RSV.
    Rengynic acid
  • HY-179634
    ASF-006 sodium Inhibitor
    ASF-006 sodium, a tetrapodal tryptophan derivative, is a potent viral invasion inhibitor. ASF-006 sodium shows potent antiviral activity against different SARS-CoV-2 Omicron variants but not against the ancestral SARS-CoV.2 strain (Wuhan-Hu-1). ASF-006 sodium competitively inhibits receptor-binding domain (RBD)-ACE2 binding via an allosteric mechanism. ASF-006 sodium inhibits Omicron BA.1, Omicron XBB.1.5, respiratory syncytial virus (RSV) and Ebola virus infection with IC50s of 0.02 μM, 0.3 μM, 1.52 μM and 0.2 μM, respectively. ASF-006 sodium inhibits cell entry of both HIV and enterovirus A71[1].
    ASF-006 sodium
  • HY-154967
    RSV L-protein-IN-4 Inhibitor
    RSV L-protein-IN-4 (Compound C) is a noncompetitive RSV polymerase inhibitor (IC50: 0.88 μM). RSV L-protein-IN-4 shows antiviral activity against RSV strains (EC50: 0.25 μM).
    RSV L-protein-IN-4
製品番号 製品名 / Synonyms Species Source
製品番号 製品名 / Synonyms Application Reactivity