ASF-006 sodium
ASF-006 sodium, a tetrapodal tryptophan derivative, is a potent viral invasion inhibitor. ASF-006 sodium shows potent antiviral activity against different SARS-CoV-2 Omicron variants but not against the ancestral SARS-CoV.2 strain (Wuhan-Hu-1). ASF-006 sodium competitively inhibits receptor-binding domain (RBD)-ACE2 binding via an allosteric mechanism. ASF-006 sodium inhibits Omicron BA.1, Omicron XBB.1.5, respiratory syncytial virus (RSV) and Ebola virus infection with IC50s of 0.02 μM, 0.3 μM, 1.52 μM and 0.2 μM, respectively. ASF-006 sodium inhibits cell entry of both HIV and enterovirus A71[1].
For research use only. We do not sell to patients.
- Formula: C125H80N8Na20O48
- Molecular Weight:2921.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ASF-006 sodium (20 μM) shows strong inhibition of infection by VSV pseudotyped, displaying Omicron BA.2 or BA.4/5 subvariants on its surface in the absence of significant toxicity to cells[1].
ASF-006 sodium against different SARS-CoV-2 Omicron variants but also highlight its limited activity against more ancestral strains (Wuhan-Hu-1) or distant coronaviruses (SARS-CoV)[1].
ASF-006 sodium shows strong antiviral activity against RSV-A, with IC50 values ranging between 0.05 and 0.2 μM when infecting A549, HEp-2, or Vero cells[1].
ASF-006 sodium shows no antiviral activity against VSV (Rhabdoviridae), Nipah virus, or Sindbis virus[1].
ASF-006 sodium interacts with the S protein, interfering with binding to its cellular receptor ACE2[1].
ASF-006 sodium binds to RBDBA.1 and SBA.1 proteins with Kd values of ∼60 μM and 5 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:K18-hACE2 (genetically modified to express human ACE2 under the control of the human cytokeratin 18 promoter; 6-week-old) were infected with SARS-CoV-2 Omicron BA.1[1]
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Dosage:100 mg/kg (50 μL)
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Administration:Intranasal; once daily; 3 days
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Result:A significant >3.5-fold reduction in viral load was observed in the lungs of treated mice compared to the vehicle group, as determined by quantitative RT-PCR.
No signs of drug toxicity were observed.
Chemical Information
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Molecular Weight 2921.79
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Formula C125H80N8Na20O48
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SMILES
O=C(C(CC1=C(C2=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C2)NC3=C1C=CC=C3C4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)NC(CCOCC(COCCC(NC(C(O[Na])=O)CC(C5=C(N6)C(C7=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C7)=CC=C5)=C6C8=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C8)=O)(COCCC(NC(CC9=C(C%10=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%10)NC%11=C9C=CC=C%11C%12=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%12)C(O[Na])=O)=O)COCCC(NC(CC%13=C(C%14=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%14)NC%15=C%13C=CC=C%15C%16=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%16)C(O[Na])=O)=O)=O)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASF-006 sodium Related Classifications
HY-179634 Related Classifications
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