ASF-006 sodium 

ASF-006 sodium, a tetrapodal tryptophan derivative, is a potent viral invasion inhibitor. ASF-006 sodium shows potent antiviral activity against different SARS-CoV-2 Omicron variants but not against the ancestral SARS-CoV.2 strain (Wuhan-Hu-1). ASF-006 sodium competitively inhibits receptor-binding domain (RBD)-ACE2 binding via an allosteric mechanism. ASF-006 sodium inhibits Omicron BA.1, Omicron XBB.1.5, respiratory syncytial virus (RSV) and Ebola virus infection with IC₅₀s of 0.02 μM, 0.3 μM, 1.52 μM and 0.2 μM, respectively. ASF-006 sodium inhibits cell entry of both HIV and enterovirus A71[1].

ASF-006 sodium (20 μM) shows strong inhibition of infection by VSV pseudotyped, displaying Omicron BA.2 or BA.4/5 subvariants on its surface in the absence of significant toxicity to cells^[1].
ASF-006 sodium against different SARS-CoV-2 Omicron variants but also highlight its limited activity against more ancestral strains (Wuhan-Hu-1) or distant coronaviruses (SARS-CoV)^[1].
ASF-006 sodium shows strong antiviral activity against RSV-A, with IC₅₀ values ranging between 0.05 and 0.2 μM when infecting A549, HEp-2, or Vero cells^[1].
ASF-006 sodium shows no antiviral activity against VSV (Rhabdoviridae), Nipah virus, or Sindbis virus^[1].
ASF-006 sodium interacts with the S protein, interfering with binding to its cellular receptor ACE2^[1].
ASF-006 sodium binds to RBDBA.1 and SBA.1 proteins with K_d values of ∼60 μM and 5 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASF-006 sodium (100 mg/kg, intranasal, once daily for 3 days) reduces viral load in a murine model of SARS-CoV-2 Omicron BA.1 infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2921.79

C₁₂₅H₈₀N₈Na₂₀O₄₈

O=C(C(CC1=C(C2=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C2)NC3=C1C=CC=C3C4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)NC(CCOCC(COCCC(NC(C(O[Na])=O)CC(C5=C(N6)C(C7=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C7)=CC=C5)=C6C8=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C8)=O)(COCCC(NC(CC9=C(C%10=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%10)NC%11=C9C=CC=C%11C%12=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%12)C(O[Na])=O)=O)COCCC(NC(CC%13=C(C%14=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%14)NC%15=C%13C=CC=C%15C%16=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C%16)C(O[Na])=O)=O)=O)O[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Martí-Marí O, et al. A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus. ACS Omega. 2025;10(46):56830-56844.   [Content Brief]