2. Signaling Pathways
  3. Immunology/Inflammation
  4. SphK

SphK

Sphingosine kinase

SphK

Related Products

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Sphingosine kinase (SphK1 and SphK2) is a lipid enzyme that catalyses the phosphorylation of sphingosine to form sphingosine 1-phosphate (S1P). Two isoforms of SphK are found in mammalian organisms, SphK1 and SphK2. SphK1 is found primarily in the cytoplasm and the plasma membrane of erythrocyte, endothelial and mast cells. SphK2 is larger and localized to the endoplasmic reticulum, nucleus, and mitochondria.

S1P binds to five different plasma membrane sphingosine 1-phosphate receptors (S1P1-5) and can regulate intracellular target proteins. S1P has a wide range of biological functions including promotion of cellular proliferation and survival, immune cell trafficking, stimulation of angiogenesis, and regulation of vascular integrity. Accumulation of S1P has been linked to the development/progression of cancer and various other diseases including, but not limited to, asthma, inflammatory bowel disease, rheumatoid arthritis, and diabetic nephropathy. Thus, the biosynthetic route to S1P is a logical target for drug discovery. SphK1 and SphK2 isozymes are also recognized therapeutic targets.

SphK Isoform Specific Products:

SphK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120152
    SLP7111228
    		Inhibitor
    SLP7111228 is a selective sphingosine kinase 1 (SphK1) inhibitor and anti-inflammatory agent. SLP7111228 selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 decreases lipopolysaccharide-induced TNFα and IL-1β levels. SLP7111228 alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 can be used in research related to neuroinflammatory diseases and pulmonary hypertension.
    SLP7111228
  • HY-RS13666
    Sphk1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sphk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sphk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sphk1 Rat Pre-designed siRNA Set A
  • HY-RS13664
    SPHK1 Human Pre-designed siRNA Set A
    		Inhibitor

    SPHK1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPHK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SPHK1 Human Pre-designed siRNA Set A
  • HY-12897
    (R)-FTY720-OMe
    		Inhibitor
    (R)-FTY720-OMe is a selective SphK2 inhibitor with an IC50 of 16.5  μM. (R)-FTY720-OMe can be used for cancer, fibrosis, and Alzheimer’s and sickle cell diseases research.
    (R)-FTY720-OMe
  • HY-RS13668
    Sphk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sphk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sphk2 Mouse Pre-designed siRNA Set A
  • HY-112385
    ABC294735
    		Inhibitor
    ABC294735 is an orally active SK1/SK2 inhibitor. Combination of ABC294735 with Sorafenib (HY-10201) reduces pERK. ABC294735 exhibits anticancer activity against pancreatic adenocarcinoma and renal cell carcinoma. ABC294735 can be used in research related to pancreatic adenocarcinoma and renal cell carcinoma.
    ABC294735
  • HY-183338
    SphK2-IN-4
    		Inhibitor
    SphK2-IN-4 is a selective SphK2 inhibitor (IC50=6.2 μM) with extremely low activity against SphK1 (IC50 > 50 μM). SphK2-IN-4 exhibits broad-spectrum antiproliferative activity against colorectal cancer cells and induces apoptosis.
    SphK2-IN-4
  • HY-120440
    VT-ME6
    		Inhibitor
    VT-ME6 is a selective SphK2 inhibitor with a Ki of 8 µM. VT-ME6 can be used in the research of inflammatory diseases.
    VT-ME6
  • HY-148262
    SphK1-IN-3
    		Inhibitor
    SphK1-IN-3 is an effective sphingosine kinase-1 (SphK1) inhibitor. SphK1-IN-3 inhibits SphK1 kinase activity with an IC50 value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such as cancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis.
    SphK1-IN-3
  • HY-RS13665
    Sphk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sphk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sphk1 Mouse Pre-designed siRNA Set A
  • HY-W019781
    Biotinylated sphingosine
    Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2.
    Biotinylated sphingosine
  • HY-101572R
    MHP (Standard)
    		Activator
    MHP (Standard) is the analytical standard of MHP (HY-101572). This product is intended for research and analytical applications. MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity.
    MHP (Standard)
  • HY-16015R
    Opaganib (Standard)
    		Inhibitor
    Opaganib (Standard) is the analytical standard of Opaganib. This product is intended for research and analytical applications. Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
    Opaganib (Standard)
  • HY-101805R
    SK1-IN-1 (Standard)
    		Inhibitor
    SK1-IN-1 (Standard) is the analytical standard of SK1-IN-1 (HY-101805). This product is intended for research and analytical applications. SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
    SK1-IN-1 (Standard)
  • HY-162580
    SphK2-IN-3
    		Inhibitor
    SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2.
    SphK2-IN-3
  • HY-108491S
    N,N-Dimethylsphingosine-13C2
    		Inhibitor
    N,N-Dimethylsphingosine-13C2 is the 13C-labeled N,N-Dimethylsphingosine (HY-108491). N,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research.
    N,N-Dimethylsphingosine-<sup>13</sup>C<sub>2</sub>
  • HY-16015A
    Opaganib hydrochloride
    		Inhibitor
    Opaganib (ABC294640) hydrochloride is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
    Opaganib hydrochloride
  • HY-12900
    RB-005
    		Inhibitor
    RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer.
    RB-005
Cat. No. Product Name / Synonyms Application Reactivity
SphK Isoform Comparison

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