SphK
Sphingosine kinase
Sphingosine kinase (SphK1 and SphK2) is a lipid enzyme that catalyses the phosphorylation of sphingosine to form sphingosine 1-phosphate (S1P). Two isoforms of SphK are found in mammalian organisms, SphK1 and SphK2. SphK1 is found primarily in the cytoplasm and the plasma membrane of erythrocyte, endothelial and mast cells. SphK2 is larger and localized to the endoplasmic reticulum, nucleus, and mitochondria.
S1P binds to five different plasma membrane sphingosine 1-phosphate receptors (S1P1-5) and can regulate intracellular target proteins. S1P has a wide range of biological functions including promotion of cellular proliferation and survival, immune cell trafficking, stimulation of angiogenesis, and regulation of vascular integrity. Accumulation of S1P has been linked to the development/progression of cancer and various other diseases including, but not limited to, asthma, inflammatory bowel disease, rheumatoid arthritis, and diabetic nephropathy. Thus, the biosynthetic route to S1P is a logical target for drug discovery. SphK1 and SphK2 isozymes are also recognized therapeutic targets.
SphK Isoform Specific Products
All Product Categories
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SphK Related Products (62)
Related Products (62)
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Antibodies (1)
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SphK Isoform Comparison
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(R)-FTY720-vinylphosphonate
0 ImagesCat. No.: HY-112485CAS No.: 1142015-25-5
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SLR080811
0 ImagesCat. No.: HY-12896CAS No.: 1449765-65-4SLR080811 is a guanidine-based selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 1.3 μM, exhibiting ~10-fold selectivity over SphK1 (Ki = 12 μM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research.
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(R)-FTY720-OMe
0 ImagesCat. No.: HY-12897CAS No.: 1382486-90-9
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ABC294735
0 ImagesCat. No.: HY-112385CAS No.: 917236-13-6ABC294735 is an orally active SK1/SK2 inhibitor. Combination of ABC294735 with Sorafenib (HY-10201) reduces pERK. ABC294735 exhibits anticancer activity against pancreatic adenocarcinoma and renal cell carcinoma. ABC294735 can be used in research related to pancreatic adenocarcinoma and renal cell carcinoma.
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SphK2-IN-4
0 ImagesCat. No.: HY-183338CAS No.: 3082221-87-9SphK2-IN-4 is a selective SphK2 inhibitor (IC50=6.2 μM) with extremely low activity against SphK1 (IC50 > 50 μM). SphK2-IN-4 exhibits broad-spectrum antiproliferative activity against colorectal cancer cells and induces apoptosis.
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VT-ME6
0 ImagesCat. No.: HY-120440CAS No.: 1353880-00-8VT-ME6 is a selective SphK2 inhibitor with a Ki of 8 µM. VT-ME6 can be used in the research of inflammatory diseases.
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SphK2-IN-5
0 ImagesCat. No.: HY-184272SphK2-IN-5 is a selective SphK2 inhibitor with an IC50 of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer.
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Biotinylated sphingosine
0 ImagesCat. No.: HY-W019781CAS No.: 752987-57-8Synonyms: Biotinyl-Sph
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MHP (Standard)
0 ImagesCat. No.: HY-101572RCAS No.: 1104874-94-3Synonyms: Methyl caprooyl tyrosinate (Standard)MHP (Standard) is the analytical standard of MHP (HY-101572). This product is intended for research and analytical applications. MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity.
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Opaganib (Standard)
0 ImagesSynonyms: ABC294640 (Standard)Opaganib (Standard) is the analytical standard of Opaganib. This product is intended for research and analytical applications. Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
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SK1-IN-1 (Standard)
0 ImagesCat. No.: HY-101805RCAS No.: 1218816-71-7
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VPC03090
0 ImagesCat. No.: HY-116516CAS No.: 1392202-91-3VPC03090 is an orally active prodrug of S1P1/3 antagonist. VPC03090 is phosphorylated by sphingosine kinase 2 (SK2) to form its active form VPC03090-P. VPC03090 reduces tumor volume in mouse breast cancer models. VPC03090 can be used in research related to breast cancer.
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SKI II hydrochloride
0 ImagesCat. No.: HY-112364CAS No.: 1177741-83-1SKI-II hydrochloride is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II hydrochloride activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. SKI-II hydrochloride inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway in vivo. SKI-II hydrochloride reduces measles virus replication by inhibiting mTORC1 activity. SKI-II hydrochloride binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II hydrochloride can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome.
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SphK2-IN-3
0 ImagesCat. No.: HY-162580CAS No.: 3047445-60-0SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2.
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N,N-Dimethylsphingosine-13C2
0 ImagesCat. No.: HY-108491SN,N-Dimethylsphingosine-13C2 is the 13C-labeled N,N-Dimethylsphingosine (HY-108491). N,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research.
