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Cat. No.: HY-16015A

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Opaganib hydrochloride

(Synonyms: ABC294640 hydrochloride)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

Opaganib (ABC294640) hydrochloride is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with K_i of 9.8 μM.

For research use only. We do not sell to patients.

CAS No.: 1185157-59-8
Formula: C₂₃H₂₆Cl₂N₂O
Molecular Weight:417.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Opaganib hydrochloride Chemical Structure

CAS No.: 1185157-59-8

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Opaganib (ABC294640) hydrochloride is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with K_i of 9.8 μM.

All SphK Isoforms :

SphK1
SphK2

Chemical Information

CAS No. 1185157-59-8
Molecular Weight 417.37
Formula C₂₃H₂₆Cl₂N₂O
SMILES

O=C(C1(C2)CC3(C4=CC=C(Cl)C=C4)CC2CC(C3)C1)NCC5=CC=NC=C5.Cl
Synonyms

ABC294640 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

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Channels

Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells. [Abstract]

2020 Dec;14(1):216-230. PMID: 32615066
Biochim Biophys Acta Mol Basis Dis

Sphingosine kinase 2 cooperating with Fyn promotes kidney fibroblast activation and fibrosis via STAT3 and AKT. [Abstract]

2018 Nov;1864(11):3824-3836. PMID: 30251698

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836. [Abstract]

NRK-49F cells are treated with TGF-β1 for the indicated time. The levels of p-STAT3, p-AKT, p-GSK3α, and p-GSK3β expression are detected in comparison with the levels of total STAT3, AKT, GSK3α, GSK3β, and with GAPDH as the loading control.
FASEB J

Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes. [Abstract]

2019 Mar;33(3):3636-3646. PMID: 30452878
Neurocrit Care

The Role of Sphingomyelin Metabolism in the Protection of Rat Brain Microvascular Endothelial Cells by Mild Hypothermia. [Abstract]

2022 Apr;36(2):546-559. PMID: 34508278
Arch Med Res

Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3. [Abstract]

2018 Jul;49(5):335-341. PMID: 30448236

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Arch Med Res. 2018 Jul;49(5):335-341. [Abstract]

Inhibition of SphK2 by si-RNA (si-SphK2) and ABC294640 (ABC) decrease phosphorylation and acetylation of STAT3 . Also, both si-RNA and ABC294640 reverse IL-6 induced increasing phosphorylation and acetylation of STAT3.
Oncotarget

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. [Abstract]

2016 Mar 29;7(13):16663-75. PMID: 26934645

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Mar 29;7(13):16663-75. [Abstract]

The western blot demonstrates the effect of ABC294640 (25 μM) for 24 h in the presence and absence of MG132 (10 μM) on Des1 expression. Actin is used a protein loading control.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. French KJ, et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39. [Content Brief]

[2]. Beljanski V, et al. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011 Dec;29(6):1132-42. [Content Brief]

[3]. Shi Y, et al. Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. 2012 Jan;56(1):137-45. [Content Brief]

[4]. Liu Q, et al. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. 2012;7(7):e41834. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Opaganib hydrochloride

6 Cited Publications

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Biological Activity
- Description
Chemical Information
Publications (6)
Purity & Documentation
References

1/16
1/16

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836. [Abstract]

Customer Validation
NRK-49F cells are treated with TGF-β1 for the indicated time. The levels of p-STAT3, p-AKT, p-GSK3α, and p-GSK3β expression are detected in comparison with the levels of total STAT3, AKT, GSK3α, GSK3β, and with GAPDH as the loading control.
1/16

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Arch Med Res. 2018 Jul;49(5):335-341. [Abstract]

Customer Validation
Inhibition of SphK2 by si-RNA (si-SphK2) and ABC294640 (ABC) decrease phosphorylation and acetylation of STAT3 . Also, both si-RNA and ABC294640 reverse IL-6 induced increasing phosphorylation and acetylation of STAT3.
1/16

Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Mar 29;7(13):16663-75. [Abstract]

Customer Validation
The western blot demonstrates the effect of ABC294640 (25 μM) for 24 h in the presence and absence of MG132 (10 μM) on Des1 expression. Actin is used a protein loading control.

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Opaganib hydrochloride

Publications Citing Use of MedChemExpress (MCE) Opaganib hydrochloride

All SphK Isoforms

Biological Activity

Chemical Information

Publications (6)

Purity & Documentation

References

Calculators

Help & FAQs

Opaganib hydrochloride Related Classifications

HY-16015A Related Classifications