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SphK Related Products (28)
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SKI II
0 ImagesSKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC50 values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. -
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Opaganib
0 ImagesSynonyms: ABC294640Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM. -
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Peretinoin
0 ImagesSynonyms: NIK333Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM. -
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N,N-Dimethylsphingosine
0 ImagesN,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research. -
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Phorbol 12-myristate 13-acetate (Standard)
0 ImagesCat. No.: HY-18739RCAS No.: 16561-29-8Synonyms: PMA (Standard); TPA (Standard); Phorbol myristate acetate (Standard)Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) (Standard) is the analytical standard of Phorbol 12-myristate 13-acetate. This product is intended for research and analytical applications. -
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SKI-349
0 ImagesSKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells. -
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- SKI-I
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SKI V
0 ImagesSKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity. -
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- SLP9101555
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- (R)-AAL
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4α-TPA
0 ImagesSynonyms: α-TPA4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events. -
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- SphK2-IN-2
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- K145
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Peretinoin (Standard)
0 ImagesSynonyms: NIK333 (Standard)Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3]. -
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PPI-4955
0 ImagesCat. No.: HY-16621CAS No.: 911412-31-2PPI-4955 is a subtype 1 (S1P₁) agonist of sphingosine-1-phosphate receptor with an EC50 of 1.62 nM. PPI-4955-P (the active phosphorylated form) exhibits excellent receptor selectivity and affinity, and the IC50 values for hS1P₁, hS1P₃, hS1P₄, and hS1P₅ are 0.23, 2000, 6.5, and 184 nM respectively. PPI-4955 has significantly improved in vivo phosphorylation efficiency, which can reduce lymphocytes and improve cardiovascular risk. PPI-4955 can be used in immunomodulation research. -
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SPHK2 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS13667 -
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(R)-FTY720-vinylphosphonate
0 ImagesCat. No.: HY-112485CAS No.: 1142015-25-5(R)-FTY720-vinylphosphonate is a sphingosine kinase 1 (SK1) inhibitor. (R)-FTY720-ene-phosphonate is also an FTY720 analogue. (R)-FTY720-vinylphosphonate is promising for research of solid tumors like breast cancer. -
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Sphk1 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS13666 -
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SPHK1 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS13664 -
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Sphk2 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS13668 -
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