1309444-75-4
1309444-75-4
Chemical Structure
K145
- CAS No.: 1309444-75-4
- Formula:C18H24N2O3S
- Molecular Weight:348.46
IUPAC Name: (Z)-3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione
InChIKey: MPZXLTZVPUSTFY-SOFYXZRVSA-N
SMILES: O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2
Biological Activity: K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity[1].
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K145 | K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. | |||||||||||||||||||||
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References
Keywords
