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Cat. No.: HY-106029

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4α-TPA

(Synonyms: α-TPA)

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Based on 1 Customer Validation

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events.

For research use only. We do not sell to patients.

Purity: 99.0%
CAS No.: 63597-44-4
Formula: C₃₆H₅₆O₈
Molecular Weight:616.83

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

4α-TPA Chemical Structure

CAS No.: 63597-44-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events^[1].

All PKC Isoforms :

All NF-κB Isoforms :

All SphK Isoforms :

SphK1
SphK2

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	EC₅₀	>17 μM Compound: 14, 4alpha-TPA	Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay	[PMID: 25970561]
MT4	EC₅₀	>18 μM Compound: 14, 4alpha-TPA	Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay	[PMID: 25970561]
Vero	CC₅₀	5.3 μM Compound: 5, 4alpha-TPA	Cytotoxicity against african green monkey Vero cells by MTS assay Cytotoxicity against african green monkey Vero cells by MTS assay	[PMID: 23215460]
Vero	EC₅₀	2.8 μM Compound: 14, 4alpha-TPA	Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days	[PMID: 25970561]
Vero	EC₅₀	2.8 μM Compound: 5, 4alpha-TPA	Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]

In Vitro

TPA (5, 50, and 100 ng/ml; 24 hours), but not 4α-TPA, induces MMP-9 enzyme activity (MMP-9 zym) and mRNA expression (MMP-9 mRNA) in U87 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 63597-44-4
Appearance Solid
Molecular Weight 616.83
Formula C₃₆H₅₆O₈
Color White to off-white
SMILES

CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Synonyms

α-TPA
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 2010;37(1):118-129. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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4α-TPA

All PKC Isoforms

All NF-κB Isoforms

All SphK Isoforms