24418-86-8
24418-86-8
Chemical Structure
SKI V
- CAS No.: 24418-86-8
- Formula:C15H10O4
- Molecular Weight:254.24
IUPAC Name: (Z)-2-(3,4-dihydroxybenzylidene)benzofuran-3(2H)-one
InChIKey: HCBULGQMULJTCM-ZSOIEALJSA-N
SMILES: O=C1/C(OC2=CC=CC=C12)=C/C3=CC=C(O)C(O)=C3
Biological Activity: SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SKI V | 98.95% | SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity. | ||||||||||||||||||||
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References
Keywords
