2. Immunology/Inflammation
  3. SphK
  4. SLP9101555

SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (Ki=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels.

For research use only. We do not sell to patients.

SLP9101555 Chemical Structure

SLP9101555 Chemical Structure

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Description

SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (Ki=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels[1].

IC50 & Target

Ki: 90 ± 11 nM (SphK2), 18000 ± 220 nM (SphK1)[1]
In Vivo

SLP9101555 (compound 14c) (5 mg/kg, IP, single) elicits profound increases in blood S1P[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 5 mg/kg
Administration: IP, single
Result: Resulted in the doubling of S1P levels in blood 4 h post dosing and returning close to baseline after 24 h.
Molecular Weight

471.95

Formula

C22H29ClF3N5O
SMILES

N=C(N1[C@H](C2=NC(C3=CC=C(CCC4CCCCC4)C(C(F)(F)F)=C3)=NO2)CCC1)N.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SLP9101555 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLP9101555SLP 9101555SLP-9101555SphKSphingosine kinaseU937human histiocytic lymphomasphingosinesphingosine-1-phosphatesphingosine kinaseInhibitorinhibitorinhibit

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