STAT6 Degrader

STAT6 Degraders (13):

製品番号	製品名	製品効果	純度

HY-169179

AK-1690	Degrader	99.91%
AK-1690 is a selective PROTAC degrader targeting STAT6 (DC₅₀=1 nM) with a K_i of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc..

HY-183733

STAT6 degrader-4	Degrader
STAT6 degrader-4 (Compound I-197) is a STAT6 degrading agent with a DC₅₀ value ranging from 1 to 10 μM. STAT6 degrader-4 can be used in cancer research.

HY-169360

SD-436	Degrader	98.27%
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC₅₀: 0.5 μM), with IC₅₀ of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma.

HY-176857

PROTAC STAT6 degrader-1	Degrader	99.55%
PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC₅₀ <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC₅₀ of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC).

HY-177456

STAT6 degrader-3	Degrader	99.26%
STAT6 degrader-3 (Compound I-1) is a potent and selective STAT6 degrader with a DC₅₀ of <1 nM. STAT6 degrader-3 can be used in the research of Type 2 immune and allergic responses.

HY-183834

PROTAC STAT6 degrader-7	Degrader
PROTAC STAT6 degrader-7 is a STAT6 PROTAC degrader with an IC₅₀ of <0.1 μM. PROTAC STAT6 degrader-7 promotes ubiquitination and degradation of STAT6. PROTAC STAT6 degrader-7 can be used in cancer research.

HY-183837

PROTAC STAT6 degrader-8	Degrader
PROTAC STAT6 degrader-8 is a STAT6 PROTAC degrader with a DC₅₀ value >0.1 μM and a DC_max value > 0.01 μM. PROTAC STAT6 degrader-8 has the potential for application in inflammation-related diseases.

HY-182699

PROTAC STAT6 degrader-5	Degrader
PROTAC STAT6 degrader-5 is a PROTAC degrader that selectively targets STAT6. PROTAC STAT6 degrader-5 induces the degradation of STAT6 protein. PROTAC STAT6 degrader-5 can be used in inflammation and cancer research.

HY-183839

PROTAC STAT6 degrader-9	Degrader
PROTAC STAT6 degrader-9 is a STAT6 PROTAC degrader with a DC₅₀ value >1 μM and a DC_max value > 0.1 μM. PROTAC STAT6 degrader-9 has the potential for application in inflammation-related diseases.

HY-171441

STAT6 degrader-1	Degrader
STAT6 degrader-1 (Compound 21) is a bifunctional molecular glue degrader of STAT6 that recruits E3 ubiquitin ligase. STAT6 degrader-1 induces proteasomal degradation of STAT6. STAT6 degrader-1 is applicable to the research of cancer, inflammatory diseases and colorectal cancer.

HY-179233

PROTAC STAT6 degrader-2	Degrader
PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases.

HY-183847

PROTAC STAT6 degrader-10	Degrader
PROTAC STAT6 degrader-10 is a STAT6 PROTAC degrader with a DC₅₀ value >1 μM and a DC_max value >0.1 μM. PROTAC STAT6 degrader-10 has the potential for application in inflammation-related diseases.

HY-181901

PROTAC STAT6 degrader-4	Degrader
PROTAC STAT6 degrader-4 (Compound 3u247) is a STAT6 PROTAC degrader with a DC₅₀ of 0.04 nM. PROTAC STAT6 degrader-4 promotes the ubiquitination and degradation of STAT6, and is applicable to the research of immune diseases.

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