country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181901

Copy Link Print Information

PROTAC STAT6 degrader-4

PROTAC STAT6 degrader-4 (Compound 3u247) is a STAT6 PROTAC degrader with a DC₅₀ of 0.04 nM. PROTAC STAT6 degrader-4 promotes the ubiquitination and degradation of STAT6, and is applicable to the research of immune diseases.

For research use only. We do not sell to patients.

CAS No.: 3103198-34-8
Formula: C₅₄H₅₇FN₁₀O₅
Molecular Weight:945.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC STAT6 degrader-4 Chemical Structure

CAS No.: 3103198-34-8

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

STAT6

0.04 nM (DC₅₀)

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

PROTAC STAT6 degrader-4 potently induces STAT6 degradation in cellular systems, with a DC₅₀ of 0.04 nM^[1].
PROTAC STAT6 degrader-4 (2 h) inhibits Eotaxin-3 release in IL-4-stimulated blood with an EC₅₀ of 0.3 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3103198-34-8
Molecular Weight 945.09
Formula C₅₄H₅₇FN₁₀O₅
SMILES

CNC1=CC(N(C=C1)C2=CC=NC3=C2C=C(N3C)CN4CC=C(CC4)C5=C(C=C(C=C5F)C(N(C6=CC=C(C=C6)C7CCN(CC7)CC8=CC9=C(N(C(N9C)=O)C%10CCC(NC%10=O)=O)C=C8)C)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renner AC, et al. Multimodal Control of STAT6 Signaling through Small-Molecule Modulation and Targeted Degradation. ACS Med Chem Lett. 2026;17(3):621-624. Published 2026 Feb 23. [Content Brief]

[2]. Patrick Stephen Johnson, et al. Stat6 degraders. WO2025207825A1. WIPO (PCT). 2025-03-26.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC STAT6 degrader-4

All PROTACs Isoforms

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC STAT6 degrader-4 Related Classifications

HY-181901 Related Classifications