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Cat. No.: HY-183847

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PROTAC STAT6 degrader-10

PROTAC STAT6 degrader-10 is a bifunctional STAT6 degrader with a DC₅₀ value of >1 μM. PROTAC STAT6 degrader-10 recruits STAT6 protein to E3 ubiquitin ligase for ubiquitination and subsequent degradation. PROTAC STAT6 degrader-10 can be used for the research of inflammatory disorders, allergies, asthma, eczema.

For research use only. We do not sell to patients.

CAS No.: 3077464-23-1
Formula: C₄₈H₆₀N₁₀O₆S
Molecular Weight:905.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC STAT6 degrader-10 Chemical Structure

CAS No.: 3077464-23-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

STAT6

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

PROTAC STAT6 degrader-10 (I-3) is a STAT6 PROTAC degrader that recruits STAT6 protein to E3 ubiquitin ligase and degrades it^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3077464-23-1
Molecular Weight 905.12
Formula C₄₈H₆₀N₁₀O₆S
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCN(C)C(C4=CC5=CC=C(C6=CCCN(C(CCN7C=CN=N7)=O)C6)C=C5N4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bin Yang, et al. Stat6 degraders and uses thereof. WO2025049820A1. 2026-02-28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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