2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT6 degrader-1

STAT6 degrader-1 (Compound 21) is a bifunctional molecular glue degrader of STAT6 that recruits E3 ubiquitin ligase. STAT6 degrader-1 induces proteasomal degradation of STAT6. STAT6 degrader-1 is applicable to the research of cancer, inflammatory diseases and colorectal cancer.

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STAT6 degrader-1

STAT6 degrader-1 Chemical Structure

CAS No. : 3063673-73-1

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STAT6 degrader-1 Related Antibodies

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Description

STAT6 degrader-1 (Compound 21) is a bifunctional molecular glue degrader of STAT6 that recruits E3 ubiquitin ligase. STAT6 degrader-1 induces proteasomal degradation of STAT6. STAT6 degrader-1 is applicable to the research of cancer, inflammatory diseases and colorectal cancer[1].

IC50 & Target

STAT6

 

Molecular Weight

1322.48

Formula

C67H78F2N7O13PS2
CAS No.
SMILES

O=C([C@H]1N2[C@](CCN(C[C@@H](C2=O)NC(C3=CC4=C(C=CC(C(F)(F)P(OCCSC(CC(C)C)=O)(OCCSC(CC(C)C)=O)=O)=C4)C=C3)=O)C(C(C5=C6)=NOC5=CC=C6C)=O)([H])CC1)N(C)CCCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7
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Room temperature in continental US; may vary elsewhere.
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References
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STAT6 degrader-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT6 degrader-13063673-73-1STATcancerinflammatory conditionsSTAT6colorectal cancerproteasomal degradationE3 ubiquitin ligaseInhibitorinhibitorinhibit

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