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Cat. No.: HY-171441

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PROTAC STAT6 degrader-11

PROTAC STAT6 degrader-11 is a STAT6 PROTAC degrader that recruits E3 ubiquitin ligase to induce degradation via the proteasomal pathway. STAT6 degrader-1 can be used in the research of cancer and inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 3063673-73-1
Formula: C₆₇H₇₈F₂N₇O₁₃PS₂
Molecular Weight:1322.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC STAT6 degrader-11 Chemical Structure

CAS No.: 3063673-73-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

STAT6

STAT3

p-STAT3

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

PROTAC STAT6 degrader-11 (Compound 21) exhibits a degradation efficiency of over 85% against total STAT6 (tSTAT6) in PBMC cells^[1].
PROTAC STAT6 degrader-11 exhibits selectivity for STAT6, with an IC₅₀ ≤ 100 nM against pSTAT6 and an IC₅₀ ≥ 3 μM against pSTAT3 in the MSD-pSTAT-PBMC assay; in the STAT6 fluorescence polarization (FP) assay, it shows an IC₅₀ ≤ 300 nM against STAT6 and an IC₅₀ > 3-30 μM against STAT3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3063673-73-1
Molecular Weight 1322.48
Formula C₆₇H₇₈F₂N₇O₁₃PS₂
SMILES

O=C([C@H]1N2[C@](CCN(C[C@@H](C2=O)NC(C3=CC4=C(C=CC(C(F)(F)P(OCCSC(CC(C)C)=O)(OCCSC(CC(C)C)=O)=O)=C4)C=C3)=O)C(C(C5=C6)=NOC5=CC=C6C)=O)([H])CC1)N(C)CCCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bifulco N, et al. Stat degraders and uses thereof. WO2024238598A2, WIPO, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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