PROTAC STAT6 degrader-1
Based on 1 Customer Validation
PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC).
(Pink: STAT6 ligand (HY-176864); Blue: Cereblon ligand (HY-45512); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 3077464-21-9
- Formula: C47H53N11O5
- Molecular Weight:851.99
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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STAT6 <1 nM (DC50) |
Chemical Information
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CAS No. 3077464-21-9
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Appearance Solid
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Molecular Weight 851.99
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Formula C47H53N11O5
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Color White to off-white
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SMILES
CN(C(N1C(CCC(N2)=O)C2=O)=O)C3=C1C=CC=C3CCCN(CC4)CCN4C5=CC=C(C6=C7C(NC(C(N(C)C)=O)=C7)=CC(C8=CCCN(C(CCN9N=NC=C9)=O)C8)=C6)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (58.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1737 mL | 5.8686 mL | 11.7372 mL | 29.3431 mL |
| 5 mM | 0.2347 mL | 1.1737 mL | 2.3474 mL | 5.8686 mL | |
| 10 mM | 0.1174 mL | 0.5869 mL | 1.1737 mL | 2.9343 mL | |
| 15 mM | 0.0782 mL | 0.3912 mL | 0.7825 mL | 1.9562 mL | |
| 20 mM | 0.0587 mL | 0.2934 mL | 0.5869 mL | 1.4672 mL | |
| 25 mM | 0.0469 mL | 0.2347 mL | 0.4695 mL | 1.1737 mL | |
| 30 mM | 0.0391 mL | 0.1956 mL | 0.3912 mL | 0.9781 mL | |
| 40 mM | 0.0293 mL | 0.1467 mL | 0.2934 mL | 0.7336 mL | |
| 50 mM | 0.0235 mL | 0.1174 mL | 0.2347 mL | 0.5869 mL |
PROTAC STAT6 degrader-1 Related Classifications
HY-176857 Related Classifications
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