PROTAC STAT6 degrader-1

Name: PROTAC STAT6 degrader-1
Brand: MedChemExpress
SKU: HY-176857
Rating: 4.5 (1 reviews)

Cat. No.: HY-176857 Purity: 99.55%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC₅₀ <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC₅₀ of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC).
(Pink: STAT6 ligand (HY-176864); Blue: Cereblon ligand (HY-45512); Black: linker).

For research use only. We do not sell to patients.

PROTAC STAT6 degrader-1 Chemical Structure

CAS No. : 3077464-21-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC₅₀ <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC₅₀ of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC)^[1]. (Pink: STAT6 ligand (HY-176864); Blue: Cereblon ligand (HY-45512); Black: linker).

IC₅₀ & Target^[1]

STAT6

<1 nM (DC₅₀)

In Vitro

PROTAC STAT6 degrader-1 (Compound I-2) induces the degradation of STAT6 HiBiT in A549 cells after 24 h, with a DC₅₀ of less than 0.1 nM and a D_max of more than 90%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

851.99

Formula

C₄₇H₅₃N₁₁O₅

CAS No.

3077464-21-9

Appearance

Solid

Color

White to off-white

SMILES

CN(C(N1C(CCC(N2)=O)C2=O)=O)C3=C1C=CC=C3CCCN(CC4)CCN4C5=CC=C(C6=C7C(NC(C(N(C)C)=O)=C7)=CC(C8=CCCN(C(CCN9N=NC=C9)=O)C8)=C6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (58.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1737 mL	5.8686 mL	11.7372 mL
5 mM	0.2347 mL	1.1737 mL	2.3474 mL
10 mM	0.1174 mL	0.5869 mL	1.1737 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Yang B, et al. Stat6 degraders and uses thereof. WO2025049820A1. 2025-03-06.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1737 mL	5.8686 mL	11.7372 mL	29.3431 mL
	5 mM	0.2347 mL	1.1737 mL	2.3474 mL	5.8686 mL
	10 mM	0.1174 mL	0.5869 mL	1.1737 mL	2.9343 mL
	15 mM	0.0782 mL	0.3912 mL	0.7825 mL	1.9562 mL
	20 mM	0.0587 mL	0.2934 mL	0.5869 mL	1.4672 mL
	25 mM	0.0469 mL	0.2347 mL	0.4695 mL	1.1737 mL
	30 mM	0.0391 mL	0.1956 mL	0.3912 mL	0.9781 mL
	40 mM	0.0293 mL	0.1467 mL	0.2934 mL	0.7336 mL
	50 mM	0.0235 mL	0.1174 mL	0.2347 mL	0.5869 mL