3077464-21-9
Chemical Structure
PROTAC STAT6 degrader-1
- CAS No.: 3077464-21-9
- Formula:C47H53N11O5
- Molecular Weight:851.99
IUPAC Name: 6-(1-(3-(1H-1,2,3-triazol-1-yl)propanoyl)-1,2,5,6-tetrahydropyridin-3-yl)-4-(4-(4-(3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propyl)piperazin-1-yl)phenyl)-N,N-dimethyl-1H-indole-2-carboxamide
InChIKey: DFVBLJKFFZPXSJ-UHFFFAOYSA-N
SMILES: CN(C(N1C(CCC(N2)=O)C2=O)=O)C3=C1C=CC=C3CCCN(CC4)CCN4C5=CC=C(C6=C7C(NC(C(N(C)C)=O)=C7)=CC(C8=CCCN(C(CCN9N=NC=C9)=O)C8)=C6)C=C5
Biological Activity: PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC)[1].
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PROTAC STAT6 degrader-1 | 99.55% | PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC). | ||||||||||||||||||||
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Keywords
