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Cat. No.: HY-183837

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PROTAC STAT6 degrader-8

PROTAC STAT6 degrader-8 is a STAT6 PROTAC degrader with a DC₅₀ value >0.1 μM and a DC_max value > 0.01 μM. PROTAC STAT6 degrader-8 has the potential for application in inflammation-related diseases.

For research use only. We do not sell to patients.

CAS No.: 3077464-49-1
Formula: C₄₁H₄₄FN₉O₆
Molecular Weight:777.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC STAT6 degrader-8 Chemical Structure

CAS No.: 3077464-49-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

STAT6

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

PROTAC STAT6 degrader-8 (I-22) is a STAT6 PROTAC degrader that recruits STAT6 protein to E3 ubiquitin ligase and degrades it^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3077464-49-1
Molecular Weight 777.84
Formula C₄₁H₄₄FN₉O₆
SMILES

O=C(N(C)C)C1=CC2=C(C(C#CCCC(N3CCN(CC3)C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=O)=CC(C6=CCCN(C6)C(CCN7N=NC=C7)=O)=C2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bin Yang, et al. Stat6 degraders and uses thereof. WO2025049820A1. 2026-02-28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC STAT6 degrader-8

All PROTACs Isoforms

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC STAT6 degrader-8 Related Classifications

HY-183837 Related Classifications