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Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Productos relacionados con Drug Derivative (3821):

Cat. No. Nombre del producto Efecto Pureza Chemical Structure
  • HY-17482
    Difenpiramide
    		99.13%
    Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity.
    Difenpiramide
  • HY-B1309
    Metacetamol
    		99.97%
    Metacetamol (AMAP) is an analog of Acetaminophen (HY-66005). Metacetamol induces dose-dependent necrosis in primary hepatocytes via glutathione depletion, mitochondrial damage, and formation of mitochondrial protein adducts. Metacetamol derivatives act as anticancer and antibacterial agents. Metacetamol can be used in studies related to breast cancer, bacterial infections, and fungal infections (candidiasis).
    Metacetamol
  • HY-176865
    Anti-inflammatory agent 106
    Anti-inflammatory agent 106 (Example 2) is a derivative of Paeonol (HY-N0159). Anti-inflammatory agent 106 has potent anti-inflammatory activity. Anti-inflammatory agent 106 effectively inhibits xylene-induced ear swelling in mouse models. Anti-inflammatory agent 106 can be used for inflammatory diseases like rheumatoid arthritis, psoriasis and type 1 diabetes research.
    Anti-inflammatory agent 106
  • HY-N9693
    Gibberellin A8
    		99.80%
    Gibberellin A8 is a derivative of Gibberellic acid (HY-N1964), a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellin A8 shows a weak growth-promoting activity on rice seedlings and oat mesocot.
    Gibberellin A8
  • HY-131286A
    Talaglumetad (hydrochloride)
    		99.58%
    Talaglumetad hydrochloride (LY-544344 hydrochloride) is an orally active prodrug of Eglumegad (HY-18941) and a metabotropic glutamate receptor 2/3 (mGluR2/3) agonist. Talaglumetad hydrochloride undergoes transmembrane transport via the intestinal peptide transporter hPepT1, and is enzymatically hydrolyzed to produce L-alanine and the parent drug Eglumegad after entering the body. Talaglumetad hydrochloride can be used in research related to metabotropic glutamate receptor 2-associated neurological systems.
    Talaglumetad (hydrochloride)
  • HY-16395
    PG-11047
    PG-11047 (CGC-11047) is a polyamine analogue. PG-11047 can be used for the research of breast cancer.
    PG-11047
  • HY-W414915
    Valsartan methyl ester
    		99.39%
    Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective and orally active angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
    Valsartan methyl ester
  • HY-180654A
    JWZ-8-103 hydrochloride
    		99.93%
    JWZ-8-103 hydrochloride is an orally active PRLX-93936 (HY-119264) analog and TRIM21-targeting molecular glue. JWZ-8-103 hydrochloride increases the thermal stability of TRIM21. JWZ-8-103 hydrochloride promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50 = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 hydrochloride has anti-cancer effects against pancreatic cancer.
    JWZ-8-103 hydrochloride
  • HY-13984
    NT-1
    		99.40%
    NT-1 (EGFR mutant-IN-3) is a potent mutant EGFR inhibitor and an analog of Osimertinib (HY-15772). This mutant EGFR inhibitor suppresses FGFRWT with an IC50 of 0.4 nM. NT-1 also inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M. NT-1 exerts deeper inhibition on p-EGFR and p-ERK, and induces tumor cell apoptosis. NT-1 can be used in colorectal cancer research.
    NT-1
  • HY-103595
    Epirizole
    		99.90%
    Epirizole (Mepirizole) is an orally active NSAID (nonsteroidal anti-inflammatory agent). Epirizole shows anti-inflammatory activity, and can be used in chronic rheumatoid arthritis research.
    Epirizole
  • HY-172314
    ACHM-025
    		Chemical 98.06%
    ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia.
    ACHM-025
  • HY-U00094
    INO5042
    		99.92%
    INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity.
    INO5042
  • HY-105808
    Furobufen
    		99.74%
    Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue.
    Furobufen
  • HY-133631
    Chloronitromethane
    		98.12%
    Chloronitromethane is one of Halonitromethanes, which are a recently identified class of disinfection by-products (DBPs) in drinking water.
    Chloronitromethane
  • HY-D0193A
    Ponceau 4R (85%)
    Ponceau 4R (85%) (Acid Red 18 (85%); New Coccine (85%)) is an orally active synthetic food colorant and a HSA-binding aggregator. Ponceau 4R (85%) binds to HSA, inducing its partial unfolding, conformational changes and aggregation. Ponceau 4R (85%) serves as a food colorant and can be used in research on diseases including type Ⅱ diabetes, Parkinson's disease, Huntington's disease and spongiform encephalopathy.
    Ponceau 4R (85%)
  • HY-14801
    Sivifene
    		99.66%
    Sivifene (A-007) is a triaryl hydrazone. Sivifene has anticancer activity and immunomodulatory effects. Sivifene regulates immune regulation by upregulating CD45 T lymphocyte surface receptors.
    Sivifene
  • HY-102001
    Tomaymycin DM
    Tomaymycin DM is a derivative of Tomaymycin (HY-N10174) that belongs to the class of DNA alkylation inhibitors and acts as an effective payload for ADCs. Tomaymycin stabilizes the double-stranded DNA structure, inhibits various DNA processing enzymes, blocks transcription, and ultimately induces DNA strand breaks and apoptosis. Tomaymycin DM can be used in studies related to the development of ADCs targeting multiple cancers including leukemia and ovarian cancer.
    Tomaymycin DM
  • HY-107831
    5-Acetylsalicylic acid
    		99.84%
    5-Acetylsalicylic acid is the derivate of Aspirin (HY-14654), with anti-inflammatory property. 5-Acetylsalicylic acid is the active metabolite of Sulfasalazine (HY-14655) and its production is regulated by beneficial bacteria in the gut but is confined to the intestinal tract. 5-Acetylsalicylic acid exhibits a mild cytotoxicity effect on B16F10 cells. 5-Acetylsalicylic acid can be used for the study of inflammatory bowel disease (IBD) such as ulcerative colitis (UC).
    5-Acetylsalicylic acid
  • HY-147251
    SRI 6409-94
    		99.25%
    SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
    SRI 6409-94
  • HY-16103
    Bitolterol mesylate
    		98.51%
    Bitolterol mesylate (WIN 37284) is a diester-type agonist amine bronchodilator without significant cardiac side effects.
    Bitolterol mesylate