2. Metabolic Enzyme/Protease Others
  3. Drug Derivative Aldose Reductase
  4. ACHM-025

ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia.

For research use only. We do not sell to patients.

ACHM-025

ACHM-025 Chemical Structure

CAS No. : 2377718-85-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

ACHM-025 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia[1].

In Vitro

ACHM-025 exhibits potent cytotoxic activity only against AKR1C3-overexpressing HCT116 cells with an IC50 of 0.03 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACHM-025 Related Antibodies
In Vivo

ACHM-025 (25 mg/kg, i.p., at days 0, 7, 14) significantly reduces the proportion of human leukemia cells in peripheral blood and prolongs survival in female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneally injection, at days 0, 7, 14
Result: Reduced the proportion of human leukemia cells in peripheral blood to <1% and maintained it for more than 10 weeks.
Extended the median event-free survival (EFS) from 16.7 days to >332 days.
Showed no relapse within the >300-day observation period, and no leukemia cells are detected in organs such as bone marrow and spleen after dissection, achieving functional cure in 5 mice.
Molecular Weight

544.62

Formula

C17H28N4O10S3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C1=CC([N+]([O-])=O)=CC=C1N(CCOS(=O)(C)=O)CCOS(=O)(C)=O)(N2CCN(CC2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (91.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8361 mL 9.1807 mL 18.3614 mL
5 mM 0.3672 mL 1.8361 mL 3.6723 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8361 mL 9.1807 mL 18.3614 mL 45.9036 mL
5 mM 0.3672 mL 1.8361 mL 3.6723 mL 9.1807 mL
10 mM 0.1836 mL 0.9181 mL 1.8361 mL 4.5904 mL
15 mM 0.1224 mL 0.6120 mL 1.2241 mL 3.0602 mL
20 mM 0.0918 mL 0.4590 mL 0.9181 mL 2.2952 mL
25 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8361 mL
30 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5301 mL
40 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1476 mL
50 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
60 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7651 mL
80 mM 0.0230 mL 0.1148 mL 0.2295 mL 0.5738 mL
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ACHM-025 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACHM-0252377718-85-7ACHM025ACHM 025Drug DerivativeAldose ReductaseDrug derivativeProdrugAKR1C3nitrogen mustard DNA alkylating agentleukemiaInhibitorinhibitorinhibit

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