Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (534)
Related Products (534)
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EMD638683 (S-Form)
0 ImagesEMD638683 (S-Form) (Compound 1a), the S-enantiomer of EMD638683 (HY-15193), is a SGK1 inhibitor with an IC50 value > 300 nM. EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer.
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(±) Anabasine-d4
0 Images(±) Anabasine-d4 is the d4-labeled (±) Anabasine (HY-W052144). (±) Anabasine is the racemic form of Anabasine (HY-B1532). (±) Anabasine stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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(±)9-HODE
0 Images(±)9-HODE is a racemate of 9-HODE. 9-HODE is a oxidized derivatives of Linoleic acid (HY-N0729).
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(R)-Birabresib
0 ImagesSynonyms: (R)-OTX-015; (R)-MK-8628(R)-Birabresib is the isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
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RYTVELA
0 ImagesRYTVELA is a deriviative of the peptide antagonist of interleukin-1 receptor 1 (IL-1R1) d-(RYTVELA) (HY-P10353) that contains all L-amino acids.
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trans-2-Undecenoic acid
0 ImagesSynonyms: (E)-2-Undecenoic acid; (E)-Undec-2-enoic acidtrans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O.
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L-Allooctopine
0 ImagesL-Allooctopine is a competitive inhibitor of D-octopine.
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(Rac)-LRK-4189
0 ImagesCat. No.: HY-175751ACAS No.: 3063345-48-9
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(±)-Taxifolin
0 ImagesSynonyms: (±)-Dihydroquercetin(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin (HY-N0136). Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
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(S)-Bleximenib
0 ImagesCat. No.: HY-155797CAS No.: 2654081-27-1Synonyms: (S)-JNJ-75276617; (S)-Menin-MLL inhibitor 24(S)-Bleximenib (Compound 28) ((S)-JNJ-75276617) is an isoform of Bleximenib (HY-148669). (S)-Bleximenib shows an IC50 greater than 1 μM in the MEIS1 mRNA expression assay. (S)-Bleximenib can be used in the research of acute myeloid leukemia.
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(±)-Mesembrenone
0 Images(±)-Mesembrenone is a mixture of two enantiomers of Mesembrenone (HY-124434). Mesembrenone is an alkaloid compound. (±)-Mesembrenone can be isolated from Sceletium tortuosum.
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GLPG0492 (R enantiomer)
0 ImagesGLPG0492 R enantiomer is the R enantiomer of GLPG0492. GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator.
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10(E)-Nonadecenoic acid
0 Images10(E)-Nonadecenoic acid is an isomer of 10Z-Nonadecenoic acid (HY-113450). 10(E)-Nonadecenoic acid is a long-chain fatty acid.
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(E)-Antibacterial agent 224
0 ImagesCat. No.: HY-161752ACAS No.: 84889-00-9(E)-Antibacterial agent 224 is an isomer of Antibacterial agent 224 (HY-161752). Antibacterial agent 224 is a potent and selective synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system.
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(+)-(1S)-Camphorquinone
0 Images(+)-(1S)-Camphorquinone is an isomer of Camphorquinone (HY-W086630). (+)-(1S)-Camphorquinone can be used as a biological material or organic compound for life science related research.
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L-Allothreonine (Standard)
0 ImagesSynonyms: H-allo-Thr-OH (Standard)L-Allothreonine (H-allo-Thr-OH) (Standard) is the analytical standard of L-Allothreonine (HY-W008315). This product is intended for research and analytical applications. L-Allothreonine is a diastereomer of L-Threonine (HY-N0658) and belongs to non-proteinogenic amino acids. L-Allothreonine serves as a non-natural substrate for yeast Cystathionine β-Synthase (HY-E70078), which is used to investigate the substrate specificity and reaction mechanism of the enzyme.
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(αR)-BI-9787
0 Images(αR)-BI-9787 is the epimer of BI-9787 (HY-161993). BI-9787 is a zwitterionic inhibitior for ketohexokinase.
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6-FITC
0 Images6-FITC (6-Fluorescein Isothiocyanate) is a fluorescein isomer and also serves as a fluorescent label for biomolecules (FITC isomers have similar excitation/emission wavelengths, which are 495 nm/519 nm in fluorescence detection).
