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Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer 関連製品 (430):

製品番号 製品名 製品効果 純度 構造式
  • HY-114395A
    (R)-NVS-ZP7-4 98.80%
    (R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.
    (R)-NVS-ZP7-4
  • HY-111191A
    (R)-ONO-2952 99.81%
    (R)-ONO-2952 is a R-enantiomer of ONO-2952. ONO-2952 is a potent, selective and orally active TSPO antagonist with Kis of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes.
    (R)-ONO-2952
  • HY-156794A
    Enzomenib enantiomer 98.01%
    Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib (HY-156794). Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC50=1.4 nM, Kd=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations.
    Enzomenib enantiomer
  • HY-W025736
    5-Amino-2-methoxyphenol
    5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research.
    5-Amino-2-methoxyphenol
  • HY-160144S2
    (rac)-Lomedeucitinib 98.11%
    (rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus.
    (rac)-Lomedeucitinib
  • HY-13250B
    Silvestrol aglycone (enantiomer) 99.10%
    Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol.
    Silvestrol aglycone (enantiomer)
  • HY-120813A
    ARN 077 (enantiomer) 99.40%
    ARN 077 enantiomer (19) is the less active enantiomer of ARN 077, with an IC50 of 3.53 μM for rat NAAA.
    ARN 077 (enantiomer)
  • HY-119580B
    (+)-Leucocyanidin 99.80%
    (+)-Leucocyanidin is the isoform of Leucocyanidin (HY-119580), is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models.
    (+)-Leucocyanidin
  • HY-114060A
    (R)-CFMB 99.75%
    (R)-CFMB is the R-enantiomer of CFMB (HY-114060). CFMB is an agonist of FFAR2- and FFAR3-specific with an EC50 value of 0.8 μM target hFFAR2 and 0.2 μM target rFFAR2.
    (R)-CFMB
  • HY-175742A
    (R)-BMS-986470 99.93%
    (R)-BMS-986470 is the enantiomer of BMS-986470 (HY-175742). BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ.
    (R)-BMS-986470
  • HY-148384B
    trans-UHMCP1
    Trans-UHMCP1 is the trans-isomer of UHMCP1 (HY-148384). UHMCP1 is a chemical probe of the U2AF homologous motif (UHM), with a Kd value of 79 μM. UHMCP1 inhibits the interaction between SF3b155/U2AF65, affecting RNA splicing and cell viability. UHMCP1 has potential anti-cancer properties.
    trans-UHMCP1
  • HY-P4633A
    D-γ-Glu-Tyr 99.70%
    D-γ-Glu-Tyr is a D-isomer of γ-Glu-Tyr (HY-P4633), the difference being the γ-Glu content.γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC50=6.77 mM), is a potentially functional component of the type 2 diabetes diet.
    D-γ-Glu-Tyr
  • HY-N6020AR
    (+)-Butin (Standard)
    (+)-Butin (Standard) is the analytical standard of (+)-Butin (HY-N6020A). This product is intended for research and analytical applications. (+)-Butin is the R-enantiomer of Butin (HY-N6020B). Butin is a bioactive flavonoid. Butin can be isolated from the heartwood of Dalbergia cocos. Butin exhibits potent antioxidant, antiplatelet, and anti-inflammatory activities.
    (+)-Butin (Standard)
  • HY-113972A
    (E/Z)-Methyl mycophenolate
    (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
    (E/Z)-Methyl mycophenolate
  • HY-123905A
    LIN28 inhibitor LI71 enantiomer 99.68%
    LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.
    LIN28 inhibitor LI71 enantiomer
  • HY-129770A
    D-Methionine sulfoxide hydrochloride 99.82%
    D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing.
    D-Methionine sulfoxide hydrochloride
  • HY-137431A
    (R)-Asundexian 99.97%
    (R)-Asundexian ((R)-BAY-2433334) is the enantiomer of Asundexian (HY-137431). (R)-Asundexian can be used in studies of cardiovascular disease, edema, and ophthalmic disease.
    (R)-Asundexian
  • HY-158107A
    (4R)-BBO-8520
    (4R)-BBO-8520 (Compound 314), an isomer of BBO-8520 (HY-158107), is a selective KRAS G12C inhibitor. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRAS G12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRASG12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state. (4R)-BBO-8520 can be used for the research of cancer.
    (4R)-BBO-8520
  • HY-141495A
    Razpipadon 99.95%
    Razpipadon ((-)-PW0464) is an isomer of (Rac)-Razpipadon (HY-141495).
    Razpipadon
  • HY-108418A
    (R)-PI3Kδ-IN-15 99.52%
    (R)-PI3Kδ-IN-15 is the R-enantiomer of PI3Kδ-IN-15 (HY-108418).
    (R)-PI3Kδ-IN-15