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Cat. No.: HY-148384B

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trans-UHMCP1

Trans-UHMCP1 is the trans-isomer of UHMCP1 (HY-148384). UHMCP1 is a chemical probe of the U2AF homologous motif (UHM), with a K_d value of 79 μM. UHMCP1 inhibits the interaction between SF3b155/U2AF⁶⁵, affecting RNA splicing and cell viability. UHMCP1 has potential anti-cancer properties.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₇N₃
Molecular Weight:297.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

trans-UHMCP1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 297.44
Formula C₁₉H₂₇N₃
SMILES

N[C@@H]1[C@@]2([H])CC[C@]1([H])CN(C(C)CCC3=CNC4=CC=CC=C34)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kobayashi A, et al. Identification of a small molecule splicing inhibitor targeting UHM domains. FEBS J. 2022 Feb;289(3):682-698. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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