2. Others Neuronal Signaling GPCR/G Protein
  3. Drug Isomer Dopamine Receptor
  4. Razpipadon

Razpipadon ((-)-PW0464) is an isomer of (Rac)-Razpipadon (HY-141495).

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Razpipadon

Razpipadon 화학구조

CAS No. : 1643489-35-3

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

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고객리뷰

Based on 1 Customer Validation

Other Forms of Razpipadon:

Razpipadon Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Razpipadon ((-)-PW0464) is an isomer of (Rac)-Razpipadon (HY-141495).

IC50 & Target

D1 Receptor

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
12 nM
Compound: 24; PW0464
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
[PMID: 31098001]
HEK293 EC50
5.3 nM
Compound: 24; PW0464
Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
[PMID: 31098001]
In Vitro

PW0464 ((Rac)-Razpipadon) is a D1 receptor agonist with an EC50 value of 5.8 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Razpipadon Related Antibodies
분자량

389.35

화학식

C19H17F2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3OC(F)F)C=C2)=C1C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (256.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5684 mL 12.8419 mL 25.6838 mL
5 mM 0.5137 mL 2.5684 mL 5.1368 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5684 mL 12.8419 mL 25.6838 mL 64.2096 mL
5 mM 0.5137 mL 2.5684 mL 5.1368 mL 12.8419 mL
10 mM 0.2568 mL 1.2842 mL 2.5684 mL 6.4210 mL
15 mM 0.1712 mL 0.8561 mL 1.7123 mL 4.2806 mL
20 mM 0.1284 mL 0.6421 mL 1.2842 mL 3.2105 mL
25 mM 0.1027 mL 0.5137 mL 1.0274 mL 2.5684 mL
30 mM 0.0856 mL 0.4281 mL 0.8561 mL 2.1403 mL
40 mM 0.0642 mL 0.3210 mL 0.6421 mL 1.6052 mL
50 mM 0.0514 mL 0.2568 mL 0.5137 mL 1.2842 mL
60 mM 0.0428 mL 0.2140 mL 0.4281 mL 1.0702 mL
80 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8026 mL
100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6421 mL
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Razpipadon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Razpipadon1643489-35-3(-)-PW0464Drug IsomerDopamine Receptordopamine receptordopamineagonistD1 ligandpsychiatric disordersInhibitorinhibitorinhibit

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Inquiry Information

상품명:
Razpipadon
Cat. No.:
HY-141495A
수량:
MCE Japan Authorized Agent:

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