(+)-Razpipadon (Synonyms: (+)-PW0464)

Cat. No.: HY-141495B: Data Sheet
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Handling Instructions
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(+)-Razpipadon ((+)-PW0464) is a selective D1 dopamine receptor agonist belonging to non-catechol compounds. (+)-Razpipadon activates the G protein pathway, while restricting β-arrestin coupling through the proximity effect of fluoromethyl-TM5, thereby achieving specific regulation of downstream pathways. (+)-Razpipadon can be used in studies related to Parkinson's disease.

For research use only. We do not sell to patients.

(+)-Razpipadon Chemical Structure

CAS No. : 1643489-51-3

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Other Forms of (+)-Razpipadon:

(Rac)-Razpipadon In-stock
Razpipadon In-stock

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

D₁ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	12 nM Compound: 24; PW0464	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	[PMID: 31098001]

In Vitro

(+)-Razpipadon is a G protein-biased agonist of human D1R that activates the G protein signaling pathway. Its potency is slightly lower than that of Tavapadon (HY-119486), but it cannot effectively activate the β-arrestin pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.35

Formula

C₁₉H₁₇F₂N₃O₄

CAS No.

1643489-51-3

SMILES

O=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3OC(F)F)C=C2)=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (256.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5684 mL	12.8419 mL	25.6838 mL
5 mM	0.5137 mL	2.5684 mL	5.1368 mL
10 mM	0.2568 mL	1.2842 mL	2.5684 mL

View the Complete Stock Solution Preparation Table

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (276 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Teng X, et al. Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun. 2022;13(1):3186. Published 2022 Jun 8. [Content Brief]

[2]. Sibley D R, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential[J]. Signal Transduction and Targeted Therapy, 2021, 6(1): 205.

[3]. Kumar S, et al. Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorg Chem. 2024;153:107809. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5684 mL	12.8419 mL	25.6838 mL	64.2096 mL
	5 mM	0.5137 mL	2.5684 mL	5.1368 mL	12.8419 mL
	10 mM	0.2568 mL	1.2842 mL	2.5684 mL	6.4210 mL
	15 mM	0.1712 mL	0.8561 mL	1.7123 mL	4.2806 mL
	20 mM	0.1284 mL	0.6421 mL	1.2842 mL	3.2105 mL
	25 mM	0.1027 mL	0.5137 mL	1.0274 mL	2.5684 mL
	30 mM	0.0856 mL	0.4281 mL	0.8561 mL	2.1403 mL
	40 mM	0.0642 mL	0.3210 mL	0.6421 mL	1.6052 mL
	50 mM	0.0514 mL	0.2568 mL	0.5137 mL	1.2842 mL
	60 mM	0.0428 mL	0.2140 mL	0.4281 mL	1.0702 mL
	80 mM	0.0321 mL	0.1605 mL	0.3210 mL	0.8026 mL
	100 mM	0.0257 mL	0.1284 mL	0.2568 mL	0.6421 mL

(+)-Razpipadon Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Razpipadon1643489-51-3(+)-PW0464Dopamine ReceptorG protein pathwayhuman D1Rβ-arrestinD1 dopamine receptortransmembrane segments 3parkinson’s diseasetransmembrane segments 7transmembrane segments 6extracellular loop 2transmembrane segments 2Inhibitorinhibitorinhibit

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