1643489-51-3
1643489-51-3
Chemical Structure
(+)-Razpipadon
Synonym(s): (+)-PW0464
- No. CAS: 1643489-51-3
- Formula:C19H17F2N3O4
- Molecular Weight:389.35
InChIKey: ZXIPVZWZRQCIRW-UHFFFAOYSA-N
SMILES: O=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3OC(F)F)C=C2)=C1C)=O
Biological Activity: (+)-Razpipadon ((+)-PW0464) is a selective D1 dopamine receptor agonist belonging to non-catechol compounds. (+)-Razpipadon activates the G protein pathway, while restricting β-arrestin coupling through the proximity effect of fluoromethyl-TM5, thereby achieving specific regulation of downstream pathways. (+)-Razpipadon can be used in studies related to Parkinson's disease[1][2].
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(+)-Razpipadon | (+)-Razpipadon ((+)-PW0464) is a selective D1 dopamine receptor agonist belonging to non-catechol compounds. (+)-Razpipadon activates the G protein pathway, while restricting β-arrestin coupling through the proximity effect of fluoromethyl-TM5, thereby achieving specific regulation of downstream pathways. (+)-Razpipadon can be used in studies related to Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Teng X, et al. Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun. 2022;13(1):3186. Published 2022 Jun 8. [Content Brief]
- [2]. Sibley D R, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential[J]. Signal Transduction and Targeted Therapy, 2021, 6(1): 205.
